| Literature DB >> 16568962 |
Laura A McAllister1, Mark S Hixon, Jack P Kennedy, Tobin J Dickerson, Kim D Janda.
Abstract
Small molecules based upon a 2-acylguanidine-5-phenyl thiophene scaffold that can activate the light chain metalloprotease of botulinum neurotoxin serotype A (BoNT LC/A) by an apparent reduction in Km are reported. On the basis of structure-activity relationships and the activation profile, one or more molecules of activator specifically bind to a defined site on the toxin, causing the observed rate enhancement. With the ever-growing clinical uses of BoNT, compounds such as those reported here may provide a method for combating the emerging adaptive immune responses to BoNT.Entities:
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Year: 2006 PMID： 16568962 PMCID： PMC2529174 DOI： 10.1021/ja057699z
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419