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Literature DB >> 16568892

Lentiviral vectors.

Abstract

We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

Entities: Species

Mesh：

Year: 2005 PMID： 16568892 DOI： 10.1007/10_007

Source DB: PubMed Journal: Adv Biochem Eng Biotechnol ISSN： 0724-6145 Impact factor: 2.635

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Cited

15 in total

Review 1. Integrase, LEDGF/p75 and HIV replication.

Authors: E M Poeschla
Journal: Cell Mol Life Sci Date: 2008-05 Impact factor: 9.261

2. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates.

Authors: Román A Barraza; Carol A Rasmussen; Nils Loewen; J Douglas Cameron; B'Ann T Gabelt; Wu-Lin Teo; Paul L Kaufman; Eric M Poeschla
Journal: Hum Gene Ther Date: 2009-03 Impact factor: 5.695

Review 3. Recent advances in lentiviral vector development and applications.

Authors: Janka Mátrai; Marinee K L Chuah; Thierry VandenDriessche
Journal: Mol Ther Date: 2010-01-19 Impact factor: 11.454

4. The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.

Authors: Chunling Hu; Dyana T Saenz; Hind J Fadel; William Walker; Mary Peretz; Eric M Poeschla
Journal: J Virol Date: 2010-09-15 Impact factor: 5.103

5. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.

Authors: Padmanabhan P Pattabiraman; Tommy Rinkoski; Eric Poeschla; Alan Proia; Pratap Challa; Ponugoti V Rao
Journal: Am J Pathol Date: 2014-12-12 Impact factor: 4.307

Review 10. Gene transfer to the outflow tract.

Authors: Yalong Dang; Ralitsa Loewen; Hardik A Parikh; Pritha Roy; Nils A Loewen
Journal: Exp Eye Res Date: 2016-04-27 Impact factor: 3.467

Lentiviral vectors.

Review 1. Integrase, LEDGF/p75 and HIV replication.

2. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates.

Review 3. Recent advances in lentiviral vector development and applications.

4. The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.

5. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.

6. Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure.

Review 7. Human gene therapy vectors derived from feline lentiviruses.

8. Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice.

Review 9. Intensive RNAi with lentiviral vectors in mammalian cells.

Review 10. Gene transfer to the outflow tract.