| Literature DB >> 16568716 |
Takuro Shimatani1, Nobuo Hosotani, Masako Ohnishi, Kazuo Kumagai, Ikutaro Saji.
Abstract
Two new human chymase inhibitors, SPF-32629A and B, were isolated from the cultured broth of Penicillium sp. SPF-32629. These structures were determined by spectroscopic methods and identified as new pyridone compounds. SPF-32629B was the carboxylated derivative of SPF-32629A. SPF-32629A and B specifically inhibited human chymase among four serine proteases tested with the IC50 of 0.25 and 0.42 microg/ml, respectively.Entities:
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Year: 2006 PMID： 16568716 DOI： 10.1038/ja.2006.5
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649