Literature DB >> 16568580

Osteoporosis-an update.

A P Lamichhane1.   

Abstract

Osteoporosis is a systemic disease characterized by decrease in bone mass per unit volume, compromised bone strength, which predisposes the affected bone to fracture. This is currently one of the leading causes of morbidity and mortality among elderly over the world. In general, osteoporosis is a silent and progressive disorder that is often brought to attention of the patients or physician only after a fracture. The aetiology of osteoporosis is multifactorial and is related to two main processes: acquisition of peak bone density that occurs at the end of the third decade and loss of bone at menopause, going on to old age. The cardinal features of osteoporosis are pain, fracture and deformity. Bone mineral density measurement is the most reliable diagnostic tool in the early stage of osteoporosis. Management of osteoporosis involves prevention and treatment. The best treatment for osteoporosis is prevention. The risk of osteoporosis can be reduced by increasing peak bone mass or by decreasing the bone loss. It needs to be emphasized that bone mineral density (BMD) peaks at about age 35 and then begins to slowly decline with significant acceleration after menopause.Therefore, the most logical and cost-effective preventive strategies are to encourage young women to stop smoking and avoid excessive use of alcohol. They should also be counseled to exercise regularly and consume adequate amounts of calcium and vitamin D.

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Mesh:

Year:  2005        PMID: 16568580

Source DB:  PubMed          Journal:  JNMA J Nepal Med Assoc        ISSN: 0028-2715            Impact factor:   0.406


  11 in total

1.  Estimation of Total Length of Femur from its Proximal and Distal Segmental Measurements of Disarticulated Femur Bones of Nepalese Population using Regression Equation Method.

Authors:  Laxman Khanal; Sandip Shah; Sarun Koirala
Journal:  J Clin Diagn Res       Date:  2017-03-01

2.  Long noncoding RNA TRG-AS1 protects against glucocorticoid-induced osteoporosis in a rat model by regulating miR-802-mediated CAB39/AMPK/SIRT-1/NF-κB axis.

Authors:  Wen Liu; Guojuan Li; Jing Li; Wei Chen
Journal:  Hum Cell       Date:  2022-07-07       Impact factor: 4.374

Review 3.  Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease Complicated With Osteoporosis.

Authors:  Weifan Xu; Yiping Jiang; Nani Wang; Huanhuan Bai; Shengyan Xu; Tianshuang Xia; Hailiang Xin
Journal:  Front Pharmacol       Date:  2022-06-01       Impact factor: 5.988

4.  The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019.

Authors:  Yuyan Shen; Xin Huang; Junyun Wu; Xiling Lin; Xiao Zhou; Zhiang Zhu; Xiaowen Pan; Jingya Xu; Jie Qiao; Tianyue Zhang; Linxia Ye; Hongwei Jiang; Yuezhong Ren; Peng-Fei Shan
Journal:  Front Endocrinol (Lausanne)       Date:  2022-05-20       Impact factor: 6.055

5.  Predictors of abnormal bone mass density in adult patients with homozygous sickle-cell disease.

Authors:  Taysir S Garadah; Adla B Hassan; Ahmed A Jaradat; Diab E Diab; Hiba O Kalafalla; Adel K Kalifa; Reginald P Sequeira; Abdul Hameed A Alawadi
Journal:  Clin Med Insights Endocrinol Diabetes       Date:  2015-05-07

6.  Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters.

Authors:  Elisabetta Barresi; Chiara Giacomelli; Laura Marchetti; Emma Baglini; Silvia Salerno; Giovanni Greco; Federico Da Settimo; Claudia Martini; Maria Letizia Trincavelli; Sabrina Taliani
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

7.  lncRNA Kcnq1ot1 promotes bone formation by inhibiting miR-98-5p/Tbx5 axis in MC3T3-E1 cells.

Authors:  Furong Wang; Fucai Zhang; Feng Zheng
Journal:  Exp Ther Med       Date:  2022-01-05       Impact factor: 2.447

Review 8.  Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment.

Authors:  Xiao-Yu He; Hai-Ming Yu; Shu Lin; Yi-Zhong Li
Journal:  Cell Mol Biol Lett       Date:  2021-11-14       Impact factor: 5.787

9.  Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway.

Authors:  Feng Gao; Sheng-Li Xia; Xiu-Hui Wang; Xiao-Xiao Zhou; Jun Wang
Journal:  J Orthop Surg Res       Date:  2021-06-21       Impact factor: 2.359

10.  Gut Microbiota Is Involved in Alcohol-Induced Osteoporosis in Young and Old Rats Through Immune Regulation.

Authors:  Ming Cheng; Bo Tan; Xiaojing Wu; Feng Liao; Fei Wang; Zuoyao Huang
Journal:  Front Cell Infect Microbiol       Date:  2021-07-14       Impact factor: 5.293

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