PURPOSE: To describe the topographical distribution of typical congenital hypertrophy of retinal pigment epithelium (CHRPE) lesions in the ocular fundi. METHODS: Retrospective review of the clinical records of 52 patients with typical unifocal CHRPE. RESULTS: The 52 CHRPE lesions ranged from 2.5 mm to 11.5 mm in maximal basal diameter (mean=6.6 mm, SD=2.6 mm). The central point of the lesion was in the peripheral fundus in 44 eyes and in the intermediate fundus in eight eyes. The footprint of the lesion involved the peripheral fundus only in 25 eyes, both the intermediate and peripheral fundus in 22 eyes, and the intermediate fundus only in five eyes. The central point of the lesion was located in the temporal quadrant in 24 eyes, the inferior quadrant in 12 eyes, the nasal quadrant in nine eyes, and the superior quadrant in seven eyes. No lesion in this series involved the posterior fundus. CONCLUSIONS: The most common fundus location for typical unifocal CHRPE in this series was the peripheral fundus temporally. Although posterior fundus location of CHRPE has been reported occasionally, our study suggests that such a location is very uncommon.
PURPOSE: To describe the topographical distribution of typical congenital hypertrophy of retinal pigment epithelium (CHRPE) lesions in the ocular fundi. METHODS: Retrospective review of the clinical records of 52 patients with typical unifocal CHRPE. RESULTS: The 52 CHRPE lesions ranged from 2.5 mm to 11.5 mm in maximal basal diameter (mean=6.6 mm, SD=2.6 mm). The central point of the lesion was in the peripheral fundus in 44 eyes and in the intermediate fundus in eight eyes. The footprint of the lesion involved the peripheral fundus only in 25 eyes, both the intermediate and peripheral fundus in 22 eyes, and the intermediate fundus only in five eyes. The central point of the lesion was located in the temporal quadrant in 24 eyes, the inferior quadrant in 12 eyes, the nasal quadrant in nine eyes, and the superior quadrant in seven eyes. No lesion in this series involved the posterior fundus. CONCLUSIONS: The most common fundus location for typical unifocal CHRPE in this series was the peripheral fundus temporally. Although posterior fundus location of CHRPE has been reported occasionally, our study suggests that such a location is very uncommon.