| Literature DB >> 1656797 |
B Adinoff1, C B Nemeroff, G Bissette, P R Martin, M Linnoila.
Abstract
The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.Entities:
Mesh：
Substances：
Year: 1991 PMID： 1656797 DOI： 10.1176/ajp.148.11.1586
Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112