Kathrin S Michelsen1, Moshe Arditi. 1. Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA.
Abstract
PURPOSE OF REVIEW: Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence has accumulated to suggest that innate immune defense mechanisms might interact with proinflammatory pathways and exacerbate or perhaps even initiate development of arterial plaques. Until recently the preponderance of such evidence has been indirectly emerging from clinical and epidemiologic studies, with some support from experimental animal models of atherosclerosis. RECENT FINDINGS: Recent data now directly implicate signaling by toll-like receptor 4 and the common adaptor molecule MyD88 in the pathogenesis of atherosclerosis, establishing a key link between atherosclerosis and defense against both foreign pathogens and endogenously generated inflammatory ligands. SUMMARY: Here we briefly review these and closely related studies, highlighting areas that should provide fertile ground for future studies aimed at a more comprehensive understanding of the interplay between innate immune defense mechanisms, atherosclerosis and related vascular disorders.
PURPOSE OF REVIEW: Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence has accumulated to suggest that innate immune defense mechanisms might interact with proinflammatory pathways and exacerbate or perhaps even initiate development of arterial plaques. Until recently the preponderance of such evidence has been indirectly emerging from clinical and epidemiologic studies, with some support from experimental animal models of atherosclerosis. RECENT FINDINGS: Recent data now directly implicate signaling by toll-like receptor 4 and the common adaptor molecule MyD88 in the pathogenesis of atherosclerosis, establishing a key link between atherosclerosis and defense against both foreign pathogens and endogenously generated inflammatory ligands. SUMMARY: Here we briefly review these and closely related studies, highlighting areas that should provide fertile ground for future studies aimed at a more comprehensive understanding of the interplay between innate immune defense mechanisms, atherosclerosis and related vascular disorders.
Authors: Huanchun Zhang; W Robert Taylor; Giji Joseph; Valentina Caracciolo; Donna M Gonzales; Neil Sidell; Emre Seli; Perry J Blackshear; Caleb B Kallen Journal: Arterioscler Thromb Vasc Biol Date: 2013-04-04 Impact factor: 8.311
Authors: Marieke Rienks; Anna Papageorgiou; Kristiaan Wouters; Wouter Verhesen; Rick van Leeuwen; Paolo Carai; Georg Summer; Dirk Westermann; Stephane Heymans Journal: Cell Mol Life Sci Date: 2016-11-23 Impact factor: 9.261