Literature DB >> 16567652

mTOR is out of control in polycystic kidney disease.

Keith E Mostov1.   

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Year:  2006        PMID： 16567652      PMCID： PMC1459339          DOI： 10.1073/pnas.0601352103

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  13 in total

Review 1.  Autosomal dominant polycystic kidney disease.

Authors:  V E Torres; P C Harris
Journal:  Nefrologia       Date:  2003       Impact factor: 2.033

2.  Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.

Authors:  Seng Hui Low; Shivakumar Vasanth; Claire H Larson; Sambuddho Mukherjee; Nikunj Sharma; Michael T Kinter; Michelle E Kane; Tomoko Obara; Thomas Weimbs
Journal:  Dev Cell       Date:  2006-01       Impact factor: 12.270

3.  The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

Authors:  Jonathan M Shillingford; Noel S Murcia; Claire H Larson; Seng Hui Low; Ryan Hedgepeth; Nicole Brown; Chris A Flask; Andrew C Novick; David A Goldfarb; Albrecht Kramer-Zucker; Gerd Walz; Klaus B Piontek; Gregory G Germino; Thomas Weimbs
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

Review 4.  Dysregulation of the TSC-mTOR pathway in human disease.

Authors:  Ken Inoki; Michael N Corradetti; Kun-Liang Guan
Journal:  Nat Genet       Date:  2005-01       Impact factor: 38.330

Review 5.  Rapamycin: an anti-cancer immunosuppressant?

Authors:  Brian K Law
Journal:  Crit Rev Oncol Hematol       Date:  2005-10       Impact factor: 6.312

Review 6.  Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

Authors:  Michael Sutters; Gregory G Germino
Journal:  J Lab Clin Med       Date:  2003-02

Review 7.  TSC2: filling the GAP in the mTOR signaling pathway.

Authors:  Yong Li; Michael N Corradetti; Ken Inoki; Kun-Liang Guan
Journal:  Trends Biochem Sci       Date:  2004-01       Impact factor: 13.807

Review 8.  Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.

Authors:  Gregory J Pazour
Journal:  J Am Soc Nephrol       Date:  2004-10       Impact factor: 10.121

9.  Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.

Authors:  Surya M Nauli; Francis J Alenghat; Ying Luo; Eric Williams; Peter Vassilev; Xiaogang Li; Andrew E H Elia; Weining Lu; Edward M Brown; Stephen J Quinn; Donald E Ingber; Jing Zhou
Journal:  Nat Genet       Date:  2003-01-06       Impact factor: 38.330

Review 10.  Cystic kidney diseases: all roads lead to the cilium.

Authors:  Qihong Zhang; Patrick D Taulman; Bradley K Yoder
Journal:  Physiology (Bethesda)       Date:  2004-08
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  10 in total

Review 1.  Autophagy in protists.

Authors:  Michael Duszenko; Michael L Ginger; Ana Brennand; Melisa Gualdrón-López; María Isabel Colombo; Graham H Coombs; Isabelle Coppens; Bamini Jayabalasingham; Gordon Langsley; Solange Lisboa de Castro; Rubem Menna-Barreto; Jeremy C Mottram; Miguel Navarro; Daniel J Rigden; Patricia S Romano; Veronika Stoka; Boris Turk; Paul A M Michels
Journal:  Autophagy       Date:  2011-02-01       Impact factor: 16.016

2.  Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis.

Authors:  P Darwin Bell; Wayne Fitzgibbon; Kelli Sas; Antine E Stenbit; May Amria; Amber Houston; Ryan Reichert; Sandra Gilley; Gene P Siegal; John Bissler; Mehmet Bilgen; Peter Cheng-te Chou; Lisa Guay-Woodford; Brad Yoder; Courtney J Haycraft; Brian Siroky
Journal:  J Am Soc Nephrol       Date:  2011-04-14       Impact factor: 10.121

Review 3.  Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease.

Authors:  Jessica Wen
Journal:  Clin Transl Sci       Date:  2011-12-07       Impact factor: 4.689

Review 4.  Polycystic kidney disease: pathogenesis and potential therapies.

Authors:  Vinita Takiar; Michael J Caplan
Journal:  Biochim Biophys Acta       Date:  2010-12-10

5.  Target of rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii.

Authors:  Sandra Díaz-Troya; Francisco J Florencio; José L Crespo
Journal:  Eukaryot Cell       Date:  2007-11-26

Review 6.  Treatment of autosomal dominant polycystic kidney disease (ADPKD): the new horizon for children with ADPKD.

Authors:  Dana Rizk; Arlene Chapman
Journal:  Pediatr Nephrol       Date:  2008-02-08       Impact factor: 3.714

7.  Revealing protein networks and gene-drug connectivity in cancer from direct information.

Authors:  Xian-Li Jiang; Emmanuel Martinez-Ledesma; Faruck Morcos
Journal:  Sci Rep       Date:  2017-06-16       Impact factor: 4.379

8.  Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.

Authors:  Ryan Centini; Mark Tsang; Terri Iwata; Heon Park; Jeffrey Delrow; Daciana Margineantu; Brandon M Iritani; Haiwei Gu; H Denny Liggitt; Janella Kang; Lim Kang; David M Hockenbery; Daniel Raftery; Brian M Iritani
Journal:  PLoS One       Date:  2018-06-13       Impact factor: 3.240

9.  The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis.

Authors:  Weiwei Liu; Yang Yi; Chuanfu Zhang; Baojuan Zhou; Lin Liao; Wenrui Liu; Jing Hu; Qiming Xu; Jie Chen; Jianrao Lu
Journal:  Front Cell Dev Biol       Date:  2021-02-09

10.  The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.

Authors:  Tiffiney R Hartman; Dongyan Liu; Jack T Zilfou; Victoria Robb; Tasha Morrison; Terry Watnick; Elizabeth P Henske
Journal:  Hum Mol Genet       Date:  2008-10-09       Impact factor: 6.150
  10 in total

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