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Literature DB >> 1656764

Rosenthal fibers contain ubiquitinated alpha B-crystallin.

Abstract

The vertebrate lens protein, alpha B-crystallin, is a major component of Rosenthal fibers (RFs) inclusion in astrocytes in Alexander's disease. Antibodies to ubiquitin bind to RFs, but it is not known whether the ubiquitin associated with RFs is bound to a specific protein or proteins, and if so, what the identity of the conjugates is. The authors have analyzed the proteins of RFs from Alexander's disease and have found mono- and polyubiquitinated conjugates of alpha B-crystallin.

Entities: Disease

Mesh：

Substances：

Year: 1991 PMID： 1656764 PMCID： PMC1886295

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

30 in total

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Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

Authors: H Mori; J Kondo; Y Ihara
Journal: Science Date: 1987-03-27 Impact factor: 47.728

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Authors: V Manetto; F W Abdul-Karim; G Perry; M Tabaton; L Autilio-Gambetti; P Gambetti
Journal: Am J Pathol Date: 1989-03 Impact factor: 4.307

4. Sequencing of proteins from two-dimensional gels by using in situ digestion and transfer of peptides to polyvinylidene difluoride membranes: application to proteins associated with sensitization in Aplysia.

Authors: T E Kennedy; M A Gawinowicz; A Barzilai; E R Kandel; J D Sweatt
Journal: Proc Natl Acad Sci U S A Date: 1988-09 Impact factor: 11.205

5. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

6. Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.

Authors: T Iwaki; A Kume-Iwaki; R K Liem; J E Goldman
Journal: Cell Date: 1989-04-07 Impact factor: 41.582

7. A study of infantile motor neuron disease with neurofilament and ubiquitin immunocytochemistry.

Authors: S Lee; Y D Park; S H Yen; H Ksiezak-Reding; J E Goldman; D W Dickson
Journal: Neuropediatrics Date: 1989-05 Impact factor: 1.947

8. Structure of polyubiquitinated histone H2A.

Authors: B E Nickel; J R Davie
Journal: Biochemistry Date: 1989-02-07 Impact factor: 3.162

9. Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease.

Authors: J Lowe; A Blanchard; K Morrell; G Lennox; L Reynolds; M Billett; M Landon; R J Mayer
Journal: J Pathol Date: 1988-05 Impact factor: 7.996

10. Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

Authors: V Manetto; G Perry; M Tabaton; P Mulvihill; V A Fried; H T Smith; P Gambetti; L Autilio-Gambetti
Journal: Proc Natl Acad Sci U S A Date: 1988-06 Impact factor: 11.205

14 in total

1. Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 2. Oligodendroglial cytoplasmic inclusions.

Authors: S Murayama; K Arima; Y Nakazato; J Satoh; M Oda; T Inose
Journal: Acta Neuropathol Date: 1992 Impact factor: 17.088

2. Alexander's disease in infancy and childhood: a report of two cases.

Authors: J W Neal; E M Cave; S K Singhrao; G Cole; S J Wallace
Journal: Acta Neuropathol Date: 1992 Impact factor: 17.088

3. Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function.

Authors: Arthur Laganowsky; Justin L P Benesch; Meytal Landau; Linlin Ding; Michael R Sawaya; Duilio Cascio; Qingling Huang; Carol V Robinson; Joseph Horwitz; David Eisenberg
Journal: Protein Sci Date: 2010-05 Impact factor: 6.725

4. Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions.

Authors: T Iwaki; T Wisniewski; A Iwaki; E Corbin; N Tomokane; J Tateishi; J E Goldman
Journal: Am J Pathol Date: 1992-02 Impact factor: 4.307

Review 5. Small heat-shock proteins: important players in regulating cellular proteostasis.

Authors: Teresa M Treweek; Sarah Meehan; Heath Ecroyd; John A Carver
Journal: Cell Mol Life Sci Date: 2014-10-29 Impact factor: 9.261

6. Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice.

Authors: A Messing; M W Head; K Galles; E J Galbreath; J E Goldman; M Brenner
Journal: Am J Pathol Date: 1998-02 Impact factor: 4.307

7. Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells.

Authors: T Wisniewski; J E Goldman
Journal: Neurochem Res Date: 1998-03 Impact factor: 3.996

8. Alpha B-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers.

Authors: T Iwaki; A Iwaki; J Tateishi; Y Sakaki; J E Goldman
Journal: Am J Pathol Date: 1993-08 Impact factor: 4.307

9. Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues.

Authors: Rainer Benndorf; Robert R Gilmont; Sahoko Hirano; Richard F Ransom; Peter R Jungblut; Martin Bommer; James E Goldman; Michael J Welsh
Journal: Cell Stress Chaperones Date: 2018-03-14 Impact factor: 3.667

10. Globular glial fibrillary acidic protein-reactive cytoplasmic inclusions in ependymoma: an immunoelectron-microscopic study.

Authors: J L Twiss; L J Anderson; D S Horoupian
Journal: Acta Neuropathol Date: 1993 Impact factor: 17.088