Literature DB >> 16565926

No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease.

Marika S Saarela1, Terho Lehtimaki, Juha O Rinne, Heini Huhtala, Riika Rontu, Antti Hervonen, Matias Roytta, Jukka-Pekka Ahonen, Kari M Mattila.   

Abstract

The brain-derived neurotrophic factor (BDNF) promotes survival, differentiation and maintenance of neurons in the central nervous system. BDNF 196 G>A and 270 C>T polymorphisms have previously been associated with Alzheimer's disease (AD) and with Parkinson's disease (PD). To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction. No associations were found between the genotypes studied and AD or PD in Finnish patients. Moreover, no interaction between either BDNF polymorphism and the epsilon 4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients.

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Year:  2006        PMID： 16565926

Source DB:  PubMed          Journal:  Folia Neuropathol        ISSN： 1509-572X            Impact factor:   2.038


  14 in total

1.  Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.

Authors:  Prosenjit Pal; Tamal Sadhukhan; Subhadip Chakraborty; Sriparna Sadhukhan; Arindam Biswas; Shyamal K Das; Kunal Ray; Jharna Ray
Journal:  Neuromolecular Med       Date:  2019-05-28       Impact factor: 3.843

2.  Sex Differences in Risk for Alzheimer's Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study.

Authors:  Joshua Matyi; JoAnn T Tschanz; Gail B Rattinger; Chelsea Sanders; Elizabeth K Vernon; Chris Corcoran; John S K Kauwe; Mona Buhusi
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-11-09       Impact factor: 6.053

Review 3.  Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.

Authors:  Tiago Martins Rodrigues; André Jerónimo-Santos; Tiago Fleming Outeiro; Ana Maria Sebastião; Maria José Diógenes
Journal:  Drugs Aging       Date:  2014-04       Impact factor: 3.923

4.  Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 genetic case-control studies of 12,563 cases and 12,622 controls.

Authors:  Huihui Ji; Dongjun Dai; Yunliang Wang; Danjie Jiang; Xingyu Zhou; Peipei Lin; Xiaosui Ji; Jinfeng Li; Yuzheng Zhang; Honglei Yin; Rongrong Chen; Lina Zhang; Mingqing Xu; Shiwei Duan; Qinwen Wang
Journal:  Exp Ther Med       Date:  2015-03-03       Impact factor: 2.447

5.  Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI.

Authors:  Alvaro Pascual-Leone; Catarina Freitas; Lindsay Oberman; Jared C Horvath; Mark Halko; Mark Eldaief; Shahid Bashir; Marine Vernet; Mouhshin Shafi; Brandon Westover; Andrew M Vahabzadeh-Hagh; Alexander Rotenberg
Journal:  Brain Topogr       Date:  2011-08-14       Impact factor: 3.020

Review 6.  Brain-derived neurotrophic factor in neurodegenerative diseases.

Authors:  Chiara Zuccato; Elena Cattaneo
Journal:  Nat Rev Neurol       Date:  2009-06       Impact factor: 42.937

7.  BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study.

Authors:  Kristina F Zdanys; Timothy G Kleiman; Huiping Zhang; Fatih Ozbay; Martha G MacAvoy; Joel Gelernter; Christopher H van Dyck
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

8.  Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration.

Authors:  Robyn A Honea; Carlos Cruchaga; Rodrigo D Perea; Andrew J Saykin; Jeffrey M Burns; Daniel R Weinberger; Alison M Goate
Journal:  PLoS One       Date:  2013-09-26       Impact factor: 3.240

Review 9.  Neurotrophic factors in Alzheimer's disease: role of axonal transport.

Authors:  K Schindowski; K Belarbi; L Buée
Journal:  Genes Brain Behav       Date:  2008-02       Impact factor: 3.449

10.  The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.

Authors:  Silke Metzger; Carolin Walter; Olaf Riess; Raymund A C Roos; Jørgen E Nielsen; David Craufurd; Huu Phuc Nguyen
Journal:  PLoS One       Date:  2013-07-22       Impact factor: 3.240
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