| Literature DB >> 16565924 |
Robert R Bies1, Matthew F Muldoon, Bruce G Pollock, Steven Manuck, Gwenn Smith, Mark E Sale.
Abstract
We describe a general and robust method for identification of an optimal non-linear mixed effects model. This includes structural, inter-individual random effects, covariate effects and residual error models using machine learning. This method is based on combinatorial optimization using genetic algorithm.Mesh:
Substances:
Year: 2006 PMID: 16565924 DOI: 10.1007/s10928-006-9004-6
Source DB: PubMed Journal: J Pharmacokinet Pharmacodyn ISSN: 1567-567X Impact factor: 2.745