RATIONALE: Nicotine and alcohol are frequently co-used, suggesting that use of one drug may facilitate use of the other. Furthermore, because men and women differ in their responses to both drugs, it is possible that men and women also differ in their responses to the combination of nicotine and alcohol. OBJECTIVE: This experiment was designed to investigate the effects of nicotine on consumption and subjective and physiological effects of alcohol in healthy male and female social drinkers. MATERIALS AND METHODS: Healthy light smoking, social drinkers (22 men and 12 women) participated in a three-session, double-blind within-subject study. They were pretreated with transdermal nicotine (7 or 14 mg) or placebo, followed two h later by an alcoholic beverage, and subsequent opportunities to "purchase" and consume more of the same drink. Outcome measures included the number of alcoholic beverages consumed and subjective and physiological effects. RESULTS:Nicotine increased alcohol consumption in men, whereas it decreased alcohol consumption in women. These effects were even more pronounced after excluding participants reporting nausea after nicotine administration. Nicotine alone increased subjective arousal in men but decreased positive mood in women. Nicotine increased the sedative-like effects of alcohol in both sexes. CONCLUSIONS: These findings indicate that both the subjective effects of nicotine and the effects of nicotine on alcohol consumption differ markedly in men and women. The findings extend existing data on sex differences in the effects of either nicotine or cigarette smoking on alcohol consumption, and support the idea that the pharmacological effects of nicotine may differ in men and women.
RCT Entities:
RATIONALE: Nicotine and alcohol are frequently co-used, suggesting that use of one drug may facilitate use of the other. Furthermore, because men and women differ in their responses to both drugs, it is possible that men and women also differ in their responses to the combination of nicotine and alcohol. OBJECTIVE: This experiment was designed to investigate the effects of nicotine on consumption and subjective and physiological effects of alcohol in healthy male and female social drinkers. MATERIALS AND METHODS: Healthy light smoking, social drinkers (22 men and 12 women) participated in a three-session, double-blind within-subject study. They were pretreated with transdermal nicotine (7 or 14 mg) or placebo, followed two h later by an alcoholic beverage, and subsequent opportunities to "purchase" and consume more of the same drink. Outcome measures included the number of alcoholic beverages consumed and subjective and physiological effects. RESULTS:Nicotine increased alcohol consumption in men, whereas it decreased alcohol consumption in women. These effects were even more pronounced after excluding participants reporting nausea after nicotine administration. Nicotine alone increased subjective arousal in men but decreased positive mood in women. Nicotine increased the sedative-like effects of alcohol in both sexes. CONCLUSIONS: These findings indicate that both the subjective effects of nicotine and the effects of nicotine on alcohol consumption differ markedly in men and women. The findings extend existing data on sex differences in the effects of either nicotine or cigarette smoking on alcohol consumption, and support the idea that the pharmacological effects of nicotine may differ in men and women.
Authors: Nadia Chaudhri; Anthony R Caggiula; Eric C Donny; Sheri Booth; Maysa A Gharib; Laure A Craven; Shannon S Allen; Alan F Sved; Kenneth A Perkins Journal: Psychopharmacology (Berl) Date: 2005-01-29 Impact factor: 4.530
Authors: Ola Blomqvist; Carlos A Hernandez-Avila; Jeffrey Van Kirk; Jed E Rose; Henry R Kranzler Journal: Alcohol Clin Exp Res Date: 2002-03 Impact factor: 3.455
Authors: Jed E Rose; Lisa H Brauer; Frederique M Behm; Matthew Cramblett; Kevin Calkins; Dawn Lawhon Journal: Nicotine Tob Res Date: 2004-02 Impact factor: 4.244
Authors: Thomas M Piasecki; Phillip K Wood; Saul Shiffman; Kenneth J Sher; Andrew C Heath Journal: Psychopharmacology (Berl) Date: 2012-04-27 Impact factor: 4.530
Authors: Sarah S Dermody; Jennifer W Tidey; Rachel L Denlinger; Lauren R Pacek; Mustafa al'Absi; David J Drobes; Dorothy K Hatsukami; Ryan Vandrey; Eric C Donny Journal: Alcohol Clin Exp Res Date: 2016-02-25 Impact factor: 3.455
Authors: Stephanie S O'Malley; Suchitra Krishnan-Sarin; Sherry A McKee; Robert F Leeman; Ned L Cooney; Boris Meandzija; Ran Wu; Robert W Makuch Journal: Int J Neuropsychopharmacol Date: 2008-09-17 Impact factor: 5.176
Authors: Sheketha R Hauser; Bruk Getachew; Scott M Oster; Ronnie Dhaher; Zheng-Ming Ding; Richard L Bell; William J McBride; Zachary A Rodd Journal: Alcohol Clin Exp Res Date: 2011-06-20 Impact factor: 3.455
Authors: Sherry A McKee; Kelly C Young-Wolff; Emily L R Harrison; K Michael Cummings; Ron Borland; Christopher W Kahler; Geoffrey T Fong; Andrew Hyland Journal: Alcohol Clin Exp Res Date: 2012-12-14 Impact factor: 3.455