| Literature DB >> 16565717 |
Annett Spudich1, Ertugrul Kilic, Hongyi Xing, Ulkan Kilic, Katharina M Rentsch, Heidi Wunderli-Allenspach, Claudio L Bassetti, Dirk M Hermann.
Abstract
The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics back into the blood against concentration gradients. We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain. We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies.Entities:
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Year: 2006 PMID： 16565717 DOI： 10.1038/nn1676
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884