Literature DB >> 16565477

The ins and outs of iron homeostasis.

Adriana Donovan1, Cindy N Roy, Nancy C Andrews.   

Abstract

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.

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Year:  2006        PMID： 16565477     DOI： 10.1152/physiol.00052.2005

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  26 in total

1.  Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1.

Authors:  Anthony C Illing; Ali Shawki; Christopher L Cunningham; Bryan Mackenzie
Journal:  J Biol Chem       Date:  2012-06-26       Impact factor: 5.157

2.  Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.

Authors:  Cindy N Roy; Howard H Mak; Imo Akpan; Grigoriy Losyev; David Zurakowski; Nancy C Andrews
Journal:  Blood       Date:  2007-01-11       Impact factor: 22.113

Review 3.  Regulation of the Iron Homeostatic Hormone Hepcidin.

Authors:  Veena Sangkhae; Elizabeta Nemeth
Journal:  Adv Nutr       Date:  2017-01-17       Impact factor: 8.701

4.  Pharmacokinetics of anti-hepcidin monoclonal antibody Ab 12B9m and hepcidin in cynomolgus monkeys.

Authors:  Jim J Xiao; Wojciech Krzyzanski; Yow-Ming Wang; Hongyan Li; Mark J Rose; Mark Ma; Yuling Wu; Beth Hinkle; Juan Jose Perez-Ruixo
Journal:  AAPS J       Date:  2010-08-25       Impact factor: 4.009

5.  Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.

Authors:  Herbert A Wetli; Peter D Buckett; Marianne Wessling-Resnick
Journal:  Chem Biol       Date:  2006-09

6.  The molecular mechanism of hepcidin-mediated ferroportin down-regulation.

Authors:  Ivana De Domenico; Diane McVey Ward; Charles Langelier; Michael B Vaughn; Elizabeta Nemeth; Wesley I Sundquist; Tomas Ganz; Giovanni Musci; Jerry Kaplan
Journal:  Mol Biol Cell       Date:  2007-05-02       Impact factor: 4.138

Review 7.  Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?

Authors:  Duygu Dee Harrison-Findik
Journal:  World J Gastroenterol       Date:  2009-03-14       Impact factor: 5.742

8.  A cytochrome b561 with ferric reductase activity from the parasitic blood fluke, Schistosoma japonicum.

Authors:  Amber Glanfield; Donald P McManus; Danielle J Smyth; Erica M Lovas; Alex Loukas; Geoffrey N Gobert; Malcolm K Jones
Journal:  PLoS Negl Trop Dis       Date:  2010-11-16

Review 9.  Physiology and pathophysiology of iron in hemoglobin-associated diseases.

Authors:  Thomas D Coates
Journal:  Free Radic Biol Med       Date:  2014-04-12       Impact factor: 7.376

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
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