John Y Choi1, Michael A Sandberg, Eliot L Berson. 1. Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Abstract
PURPOSE: To estimate mean rates of change of ocular function in patients with pigmented paravenous retinochoroidal atrophy (PPRCA). DESIGN: Retrospective observational case series. METHODS: Fifteen patients aged 8 to 67 years with PPRCA were followed for 3 to 35 years (average follow-up time, 13 years) with measures of visual acuity, visual field area, and full-field electroretinogram amplitude. Mean annual exponential rates of change were quantified by repeated measures longitudinal regression. RESULTS: Estimated mean annual rates of change were -2.0% for visual acuity, +0.3% for visual field area, and -3.4% and -6.7% for 0.5 Hz and 30 Hz electroretinogram amplitudes, respectively. CONCLUSION: Patients with PPRCA have a slowly progressive disease with respect to the loss of peripheral vision.
PURPOSE: To estimate mean rates of change of ocular function in patients with pigmented paravenous retinochoroidal atrophy (PPRCA). DESIGN: Retrospective observational case series. METHODS: Fifteen patients aged 8 to 67 years with PPRCA were followed for 3 to 35 years (average follow-up time, 13 years) with measures of visual acuity, visual field area, and full-field electroretinogram amplitude. Mean annual exponential rates of change were quantified by repeated measures longitudinal regression. RESULTS: Estimated mean annual rates of change were -2.0% for visual acuity, +0.3% for visual field area, and -3.4% and -6.7% for 0.5 Hz and 30 Hz electroretinogram amplitudes, respectively. CONCLUSION:Patients with PPRCA have a slowly progressive disease with respect to the loss of peripheral vision.
Authors: Jason Comander; Carol Weigel-DiFranco; Matthew Maher; Emily Place; Aliete Wan; Shyana Harper; Michael A Sandberg; Daniel Navarro-Gomez; Eric A Pierce Journal: Genes (Basel) Date: 2017-10-05 Impact factor: 4.096