OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM RATING: B-2b.
OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRSpatients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRSpatients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRSpatients and correlates with disease severity. EBM RATING: B-2b.
Authors: Yohan Bossé; François Bacot; Alexandre Montpetit; Johan Rung; Hui-Qi Qu; James C Engert; Constantin Polychronakos; Thomas J Hudson; Philippe Froguel; Robert Sladek; Martin Desrosiers Journal: Hum Genet Date: 2009-01-29 Impact factor: 4.132
Authors: Joy Hsu; Pedro C Avila; Robert C Kern; M Geoffrey Hayes; Robert P Schleimer; Jayant M Pinto Journal: J Allergy Clin Immunol Date: 2013-04 Impact factor: 10.793
Authors: Ignacio Dávila; Carmen Rondón; Ana Navarro; Encarnación Antón; Carlos Colás; María Teresa Dordal; María Dolores Ibáñez; Beatriz Fernández-Parra; Magdalena Lluch-Bernal; Víctor Matheu; Javier Montoro; María Cesárea Sánchez; Antonio Valero Journal: Am J Rhinol Allergy Date: 2012 Sep-Oct Impact factor: 2.467