| Literature DB >> 16564114 |
Tomoya Nakamachi1, Min Li, Seiji Shioda, Akira Arimura.
Abstract
Activity-dependent neurotrophic protein (ADNP) was discovered as a novel response gene for VIP and has neuroprotective potential. When the VIP paralog, PACAP38 was added to mouse neuron-glia co-cultures, it induced ADNP mRNA expression in a bimodal fashion at subpico- and nanomolar concentrations with greater response at subpicomolar level. The response was attenuated by a PAC1-R antagonist at both concentrations and by a VPAC1-R antagonist at nanomolar concentration only. An IP3/PLC inhibitor attenuated the response at both concentrations of PACAP38, but a MAPK inhibitor had no effect. A PKA inhibitor suppressed the response at nanomolar concentration only. These findings suggest that ADNP expression is mediated through multiple receptors and signaling pathways that are regulated by different concentrations of PACAP.Entities:
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Year: 2006 PMID： 16564114 DOI： 10.1016/j.peptides.2006.01.007
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750