Literature DB >> 16564110

Pharmacogenetic studies of epilepsy drugs: are we there yet?

Nigel K Spurr1.   

Abstract

One of the mantras of scientists working in the field of pharmacogenetics is 'the right dose for the right patient'. A recent article has gone someway towards demonstrating that this goal can be achieved using genetic approaches. It is one of the first reports to show that a specific polymorphism can predict the maximum tolerated dose of two anti-epileptic drugs. However, further studies are necessary to validate these observations.

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Year:  2006        PMID: 16564110     DOI: 10.1016/j.tig.2006.03.004

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  1 in total

1.  Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.

Authors:  Loredana Stoica; Ping Jun Zhu; Wei Huang; Hongyi Zhou; Sara C Kozma; Mauro Costa-Mattioli
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-09       Impact factor: 11.205

  1 in total

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