| Literature DB >> 16564003 |
Andreas Wodarz1, Cayetano Gonzalez.
Abstract
Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.Entities:
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Year: 2006 PMID： 16564003 DOI： 10.1016/j.cell.2006.03.004
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582