Literature DB >> 16563758

New potential biologically active compounds: design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation.

Shujiang Tu1, Xiaotong Zhu, Jinpeng Zhang, Jianing Xu, Yan Zhang, Qian Wang, Runhong Jia, Bo Jiang, Junyong Zhang, Changsheng Yao.   

Abstract

A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening.

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Year:  2006        PMID: 16563758     DOI: 10.1016/j.bmcl.2006.03.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.

Authors:  Victoria V Lipson; Nikolay Yu Gorobets
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

Review 2.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

3.  Lithium Perchlorate-, Acetic Anhydride-, and Triphenylphosphine-assisted Multicomponent Syntheses of 4-Unsubstituted 2,5-Dioxooctahydroquinoline-3-carboxylates and 3-carbonitriles.

Authors:  Xingxian Gu; Gunda I Georg
Journal:  Tetrahedron       Date:  2013-09-05       Impact factor: 2.457

4.  Ethyl 3-(2,4-dioxocyclohexyl)propanoate as a novel precursor for N-substituted 4,4a,5,6-tetrahydroquinoline-2,7(1H,3H)-diones and their corresponding 3,4-dihydro-7-hydroxyquinolin-2(1H)-ones and 7-hydroxyquinolin-2(1H)-ones synthesis.

Authors:  Vandna Thakur; Dharminder Sharma; Pralay Das
Journal:  Mol Divers       Date:  2015-11-04       Impact factor: 2.943

5.  Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines.

Authors:  Christopher G Evans; Jason E Gestwicki
Journal:  Org Lett       Date:  2009-07-16       Impact factor: 6.005

6.  Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole.

Authors:  Nilesh J Thumar; Manish P Patel
Journal:  Saudi Pharm J       Date:  2011-02-03       Impact factor: 4.330

  6 in total

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