Literature DB >> 16563756

Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate.

Yuqiang Wang1, Lianfa Li, Wei Jiang, Zhaoqi Yang, Zaijun Zhang.   

Abstract

A conjugate of DHA and doxorubicin (DHA-Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA-Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.

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Year:  2006        PMID： 16563756     DOI： 10.1016/j.bmcl.2006.02.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

Review 1.  Lipid-Drug Conjugate for Enhancing Drug Delivery.

Authors:  Danielle Irby; Chengan Du; Feng Li
Journal:  Mol Pharm       Date:  2017-01-24       Impact factor: 4.939

Review 2.  Lipid-based drug carriers for prodrugs to enhance drug delivery.

Authors:  Jennica L Zaro
Journal:  AAPS J       Date:  2014-10-01       Impact factor: 4.009

3.  Peroxisome proliferator-activated receptors (PPARs) in dermatology: Challenge and promise.

Authors:  Pit Sertznig; Jörg Reichrath
Journal:  Dermatoendocrinol       Date:  2011-07-01

4.  Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia.

Authors:  Satvir Sekhon-Loodu; Ziaullah Ziaullah; H P Vasantha Rupasinghe; Yanwen Wang; Marianna Kulka; Fereidoon Shahidi
Journal:  Inflammopharmacology       Date:  2015-07-14       Impact factor: 4.473

Review 5.  Designer lipids for drug delivery: from heads to tails.

Authors:  Aditya G Kohli; Paul H Kierstead; Vincent J Venditto; Colin L Walsh; Francis C Szoka
Journal:  J Control Release       Date:  2014-05-06       Impact factor: 9.776

6.  Targeted sialic acid-doxorubicin prodrugs for intracellular delivery and cancer treatment.

Authors:  Sreeja Jayant; Jayant J Khandare; Yang Wang; Ajay P Singh; Nicholi Vorsa; Tamara Minko
Journal:  Pharm Res       Date:  2007-08-01       Impact factor: 4.200

7.  The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabine-loaded micelles on drug resistance caused by RRM1 overexpression.

Authors:  Saijie Zhu; Piyanuch Wonganan; Dharmika S P Lansakara-P; Hannah L O'Mary; Yue Li; Zhengrong Cui
Journal:  Biomaterials       Date:  2012-12-20       Impact factor: 12.479

8.  Docosahexaenoic acid induces dose dependent cell death in an early undifferentiated subtype of acute myeloid leukemia cell line.

Authors:  Takashi Yamagami; Christopher D Porada; Ronald S Pardini; Esmail D Zanjani; Graça Almeida-Porada
Journal:  Cancer Biol Ther       Date:  2009-02-03       Impact factor: 4.742

9.  On the interaction of doxorubicin with oleate ions: fluorescence spectroscopy and liquid-liquid extraction study.

Authors:  Emilie Munnier; Frédéric Tewes; Simone Cohen-Jonathan; Claude Linassier; Laurence Douziech-Eyrolles; Hervé Marchais; Martin Soucé; Katel Hervé; Pierre Dubois; Igor Chourpa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2007-07       Impact factor: 1.645

10.  4-(N)-Docosahexaenoyl 2', 2'-difluorodeoxycytidine induces immunogenic cell death in colon and pancreatic carcinoma models as a single agent.

Authors:  Stephanie Hufnagel; Haiyue Xu; Michael F Colemam; Solange A Valdes; Kristyn A Liu; Stephen D Hursting; Zhengrong Cui
Journal:  Cancer Chemother Pharmacol       Date:  2021-10-26       Impact factor: 3.333
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