Literature DB >> 16563755

Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase.

Scott R Walker1, Emily J Parker.   

Abstract

The first mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from D-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.

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Year:  2006        PMID： 16563755     DOI： 10.1016/j.bmcl.2006.02.073

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.

Authors:  Sebastian Reichau; Wanting Jiao; Scott R Walker; Richard D Hutton; Edward N Baker; Emily J Parker
Journal:  J Biol Chem       Date:  2011-03-15       Impact factor: 5.157

2.  Functionalization of α-hydroxyphosphonates as a convenient route to N-tosyl-α-aminophosphonates.

Authors:  Tomasz Cytlak; Monika Skibińska; Patrycja Kaczmarek; Marcin Kaźmierczak; Magdalena Rapp; Maciej Kubicki; Henryk Koroniak
Journal:  RSC Adv       Date:  2018-03-27       Impact factor: 4.036
  2 in total

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