Literature DB >> 16563752

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

Jay P Powers1, Shyun Li, Juan C Jaen, Jinqian Liu, Nigel P C Walker, Zhulun Wang, Holger Wesche.   

Abstract

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.

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Year:  2006        PMID： 16563752     DOI： 10.1016/j.bmcl.2006.03.020

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  37 in total

1.  A novel aminosaccharide compound blocks immune responses by Toll-like receptors and nucleotide-binding domain, leucine-rich repeat proteins.

Authors:  Kyoung-Hee Lee; Yuen-Joyce Liu; Amlan Biswas; Chikako Ogawa; Koichi S Kobayashi
Journal:  J Biol Chem       Date:  2010-12-07       Impact factor: 5.157

2.  Oncogenically active MYD88 mutations in human lymphoma.

Authors:  Vu N Ngo; Ryan M Young; Roland Schmitz; Sameer Jhavar; Wenming Xiao; Kian-Huat Lim; Holger Kohlhammer; Weihong Xu; Yandan Yang; Hong Zhao; Arthur L Shaffer; Paul Romesser; George Wright; John Powell; Andreas Rosenwald; Hans Konrad Muller-Hermelink; German Ott; Randy D Gascoyne; Joseph M Connors; Lisa M Rimsza; Elias Campo; Elaine S Jaffe; Jan Delabie; Erlend B Smeland; Richard I Fisher; Rita M Braziel; Raymond R Tubbs; J R Cook; Denny D Weisenburger; Wing C Chan; Louis M Staudt
Journal:  Nature       Date:  2010-12-22       Impact factor: 49.962

3.  Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis.

Authors:  Peter J Wermuth; Sergio A Jimenez
Journal:  J Immunol       Date:  2012-05-30       Impact factor: 5.422

4.  Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies.

Authors:  Zhaoyang Li; Kenisha Younger; Ronald Gartenhaus; Ann Mary Joseph; Fang Hu; Maria R Baer; Patrick Brown; Eduardo Davila
Journal:  J Clin Invest       Date:  2015-02-02       Impact factor: 14.808

5.  Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway.

Authors:  Sumanta Kumar Naik; Avinash Padhi; Geetanjali Ganguli; Srabasti Sengupta; Sanghamitra Pati; Dasarathi Das; Avinash Sonawane
Journal:  Infect Immun       Date:  2017-09-20       Impact factor: 3.441

6.  TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib.

Authors:  Adrian Wiestner; Sarah E M Herman; Eman L Dadashian; Erin M McAuley; Delong Liu; Arthur L Shaffer; Ryan M Young; Jessica R Iyer; Michael J Kruhlak; Louis M Staudt
Journal:  Cancer Res       Date:  2018-11-29       Impact factor: 12.701

7.  Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles.

Authors:  Julie A Pollock; Sung Hoon Kim; John A Katzenellenbogen
Journal:  Tetrahedron Lett       Date:  2015-10-28       Impact factor: 2.415

8.  Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

Authors:  Kaiwei Liang; Andrew G Volk; Jeffrey S Haug; Stacy A Marshall; Ashley R Woodfin; Elizabeth T Bartom; Joshua M Gilmore; Laurence Florens; Michael P Washburn; Kelly D Sullivan; Joaquin M Espinosa; Joseph Cannova; Jiwang Zhang; Edwin R Smith; John D Crispino; Ali Shilatifard
Journal:  Cell       Date:  2017-01-05       Impact factor: 41.582

Review 9.  Targeting Toll-like receptors for treatment of SLE.

Authors:  Christopher G Horton; Zi-jian Pan; A Darise Farris
Journal:  Mediators Inflamm       Date:  2010-09-19       Impact factor: 4.711

10.  Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

Authors:  Qiu Wang; Stuart L Schreiber
Journal:  Org Lett       Date:  2009-11-19       Impact factor: 6.005
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