| Literature DB >> 16563392 |
Nathan A Davies1, Stephen J Hodges, Andrew A Pitsillides, Rajeshwar P Mookerjee, Rajiv Jalan, Siroos Mehdizadeh.
Abstract
The production of nitric oxide (NO) in liver disease and its role in vascular control has been a subject of much interest in recent years. However, the activity of guanylate cyclase (GC), the enzyme activated by NO has received little attention with regard to liver disease. In this study we have utilised a quantitative cytochemical technique to examine the activity of GC on a per cell basis in a rat model of cirrhosis. Our results show a significant reduction in GC activity, indicating that vascular regulation is likely to be substantially affected irrespective of NO generation in this disease model.Entities:
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Year: 2006 PMID： 16563392 DOI： 10.1016/j.febslet.2006.02.080
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124