| Literature DB >> 16562850 |
Sudarat Homhual1, Nuntavan Bunyapraphatsara, Tamara Kondratyuk, Angkana Herunsalee, Wongsatit Chaukul, John M Pezzuto, Harry H S Fong, Hong-Jie Zhang.
Abstract
Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC(50) values of 7.8, 9.4, and 15.7 microM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFkappaB (nuclear factor-kappaB) luciferase activation with an IC(50) value of 1.4 microM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC(50) value of 0.37 microM. Compounds 2 and 3 were not active in these bioassays.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16562850 DOI： 10.1021/np058112x
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050