| Literature DB >> 16562837 |
Zakaria H Mbwambo1, Modest C Kapingu, Mainen J Moshi, Francis Machumi, Sandra Apers, Paul Cos, Daneel Ferreira, Jannie P J Marais, Dirk Vanden Berghe, Louis Maes, Arnold Vlietinck, Luc Pieters.
Abstract
A new biflavanoid, ent-naringeninyl-(I-3alpha,II-8)-4'-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC(50) 6.7 microM). Antitrypanosomal activity (IC(50) 0.87 microM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM).Entities:
Mesh：
Substances：
Year: 2006 PMID： 16562837 DOI： 10.1021/np050406v
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050