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Literature DB >> 1655989

Anti-histone antibodies in subacute sensory neuropathy.

M Monestier¹, T M Fasy, L Bohm, F S Lieberman.

Abstract

We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sensory neuropathy. IgG antibodies to histones H1 and H3 were significantly elevated in 4 of these patients. The anti-H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-terminal domain of the H1 molecule. We also observed reactivity of these sera with histone H1 zero, a variant found in terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve as autoantigens in humorally-mediated paraneoplastic diseases.

Entities: Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1655989 DOI： 10.1007/bf00167000

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

14 in total

1. Monoclonal anti-histone H1 autoantibodies from MRL lpr/lpr mice.

Authors: M Monestier; T M Fasy; L Böhm
Journal: Mol Immunol Date: 1989-08 Impact factor: 4.407

2. Antihistone antibodies in systemic lupus erythematosus.

Authors: R L Rubin; S Waga
Journal: J Rheumatol Suppl Date: 1987-06

3. Immunofluorescent localization of histone H10 in the nuclei of proliferating and differentiating Friend cells.

Authors: T Banchev; L Srebreva; J Zlatanova; R Tsanev
Journal: Exp Cell Res Date: 1988-07 Impact factor: 3.905

4. Studies on histones. 7. Preparative methods for histone fractions from calf thymus.

Authors: E W Johns
Journal: Biochem J Date: 1964-07 Impact factor: 3.857

Review 5. Microheterogeneity in H1 histones and its consequences.

Authors: R D Cole
Journal: Int J Pept Protein Res Date: 1987-10

Review 6. Proteases as structural probes for chromatin: the domain structure of histones.

Authors: L Böhm; C Crane-Robinson
Journal: Biosci Rep Date: 1984-05 Impact factor: 3.840

7. Differential kinetics of histone H1(0) accumulation in neuronal and glial cells from rat cerebral cortex during postnatal development.

Authors: B Piña; P Martínez; L Simón; P Suau
Journal: Biochem Biophys Res Commun Date: 1984-09-17 Impact factor: 3.575

Anti-histone antibodies in subacute sensory neuropathy.

1. Monoclonal anti-histone H1 autoantibodies from MRL lpr/lpr mice.

2. Antihistone antibodies in systemic lupus erythematosus.

3. Immunofluorescent localization of histone H10 in the nuclei of proliferating and differentiating Friend cells.

4. Studies on histones. 7. Preparative methods for histone fractions from calf thymus.

Review 5. Microheterogeneity in H1 histones and its consequences.

Review 6. Proteases as structural probes for chromatin: the domain structure of histones.

7. Differential kinetics of histone H1(0) accumulation in neuronal and glial cells from rat cerebral cortex during postnatal development.

8. The distribution of the histone H1o in different brain cell types.

9. Autoantibodies in paraneoplastic syndromes associated with small-cell lung cancer.

10. Antibodies in procainamide-induced and systemic lupus erythematosus bind the C-terminus of histone 1 (H1).

Review 1. Role of peroxynitrite-modified biomolecules in the etiopathogenesis of systemic lupus erythematosus.