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Literature DB >> 16557837

Immunity in Experimental Salmonellosis I. Protection Induced by Rough Mutants of Salmonella typhimurium.

Abstract

Different rough mutants of Salmonella typhimurium were tested to determine their virulence and immunizing capacity when used as live vaccines for mice. All uridine diphosphate-galactose-4-epimeraseless mutants tested were much more potent immunizing agents than any other mutants. This capacity was not correlated with virulence or complexity of cell wall polysaccharide. For good protection, persistence of the rough strains in vivo was essential, but the protection lasted longer than the period during which bacteria were demonstrable in the liver and spleen of the mice. The outstanding immunizing capacity of the "epimeraseless" mutants is not dependent on the persistence of viable bacteria in the mouse.

Entities: Chemical Disease Species

Year: 1970 PMID： 16557837 PMCID： PMC416007 DOI： 10.1128/iai.2.3.309-315.1970

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. ROUGH MUTANTS OF SALMONELLA TYPHIMURIUM. III. ENZYMATIC SYNTHESIS OF NUCLEOTIDE-SUGAR COMPOUNDS.

Authors: H NIKAIDO; K MIKAIDO; T V SUBBAIAH; B A STOCKER
Journal: Nature Date: 1964-03-28 Impact factor: 49.962

Review 2. BASIS FOR IMMUNITY TO TYPHOID IN MICE AND THE QUESTION OF "CELLULAR IMMUNITY".

Authors: C R JENKIN; D ROWLEY
Journal: Bacteriol Rev Date: 1963-12

3. Mutants of Salmonella with unusually low toxicity for mice.

Authors: M NAKANO
Journal: Nature Date: 1962-12-15 Impact factor: 49.962

4. The sensitivity of smooth and rough mutants of Salmonella typhimurium to bactericidal and bacteriolytic action of serum, lysozyme and to phagocytosis.

Authors: V Dlabac
Journal: Folia Microbiol (Praha) Date: 1968 Impact factor: 2.099

5. Further studies regarding the question of cellular immunity in mouse typhoid.

Authors: D Rowley; I Auzins; C R Jenkin
Journal: Aust J Exp Biol Med Sci Date: 1968-08

6. A proposed mechanism for natural immunity to enterobacterial pathogens.

Authors: L Chedid; M Parant; F Parant; F Boyer
Journal: J Immunol Date: 1968-02 Impact factor: 5.422

7. Genetics and cultural properties of mutants of Salmonella typhimurium lacking glucosyl or galactosyl lipopolysaccharide transferases.

Authors: R G Wilkinson; B A Stocker
Journal: Nature Date: 1968-03-09 Impact factor: 49.962

8. Two types of immunity in experimental typhoid; "cellular immunity" and "humoral immunity".

Authors: D Ushiba
Journal: Keio J Med Date: 1965-06

9. Recall of immunity in mice vaccinated with Salmonella enteritidis or Salmonella typhimurium.

Authors: F M Collins
Journal: J Bacteriol Date: 1968-06 Impact factor: 3.490

Review 10. LIPOPOLYSACCHARIDE OF THE GRAM-NEGATIVE CELL WALL.

Authors: M J OSBORN; S M ROSEN; L ROTHFIELD; L D ZELEZNICK; B L HORECKER
Journal: Science Date: 1964-08-21 Impact factor: 47.728

20 in total

1. Immunity in experimental salmonellosis. 3. Comparative immunization with viable and heat-inactivated cells of Salmonella typhimurium.

Authors: R Germanier
Journal: Infect Immun Date: 1972-05 Impact factor: 3.441

Review 2. Vaccines and cell-mediated immunity.

Authors: F M Collins
Journal: Bacteriol Rev Date: 1974-12

3. The immunization of mice and calves with gal E mutants of Salmonella typhimurium.

Authors: C Wray; W J Sojka; J A Morris; W J Brinley Morgan
Journal: J Hyg (Lond) Date: 1977-08

4. Immunity in experimental salmonellosis. II. Basis for the avirulence and protective capacity of gal E mutants of Salmonella typhimurium.

Authors: R Germanier; E Fürer
Journal: Infect Immun Date: 1971-12 Impact factor: 3.441

9. The effect of T and B lymphocyte depletion on the protection of mice vaccinated with a Gal E mutant of Salmonella typhimurium.

Authors: J A Morris; C Wray; W J Sojka
Journal: Br J Exp Pathol Date: 1976-06

10. Safety, infectivity, immunogenicity, and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans.

Authors: M M Levine; D Herrington; J R Murphy; J G Morris; G Losonsky; B Tall; A A Lindberg; S Svenson; S Baqar; M F Edwards
Journal: J Clin Invest Date: 1987-03 Impact factor: 14.808