OBJECTIVES: To compare the single thermal indicator dilution (STID) technique for measurement of extravascular lung water (EVLW(STID)) with gravimetrically determined EVLW (EVLW(GRAV)) in anesthetized pigs under sham and endotoxemic conditions. DESIGN: Open experimental comparative animal study. SETTING: University animal research laboratory. SUBJECTS: Fifteen anesthetized landrace pigs. INTERVENTIONS: Endotoxin infusion during 5 hrs in five pigs. Six animals were only anesthetized and rested for 5 hrs. In four additional animals, the impact on EVLW(STID) measurements by changes in pulmonary perfusion, ventilation, and the combination of the two was studied. The alterations in ventilation and perfusion were induced by caval balloon inflation, inflation of the pulmonary artery catheter balloon, and bronchial plugging respectively. MEASUREMENTS AND MAIN RESULTS: The STID technique, with default settings of the intrathoracic blood volume (ITBV) to global end-diastolic volume (GEDV) (i.e., the extrapulmonary intravascular volume between the point of injection of the indicator, and the point of detection) relationship (ITBV = 1.25GEDV), systematically overestimated the EVLW index compared with the gravimetrical method (mean bias of 5.4 mL/kg). By adapting the ITBV to GEDV relationship to the current model (ITBV = 1.52GEDV + 49.7), the accuracy of the STID technique improved. Moreover, the measurement of EVLW(STID) proved to be reduced by manipulation of pulmonary perfusion and ventilation. However, the STID technique could detect an increase in EVLW during endotoxemia independent of the ITBV/GEDV relationship used. CONCLUSION: Despite technological improvement, the dilution techniques for the measurement of EVLW might still be influenced by changes in perfusion and ventilation. The STID technique, in addition, might demand adjustment of the ITBV/GEDV relationship to the particular condition and species subjected to measurement. The STID technique may, however, be a useful tool for monitoring changes of EVLW over time, but further studies are warranted to confirm this.
OBJECTIVES: To compare the single thermal indicator dilution (STID) technique for measurement of extravascular lung water (EVLW(STID)) with gravimetrically determined EVLW (EVLW(GRAV)) in anesthetized pigs under sham and endotoxemic conditions. DESIGN: Open experimental comparative animal study. SETTING: University animal research laboratory. SUBJECTS: Fifteen anesthetized landrace pigs. INTERVENTIONS: Endotoxin infusion during 5 hrs in five pigs. Six animals were only anesthetized and rested for 5 hrs. In four additional animals, the impact on EVLW(STID) measurements by changes in pulmonary perfusion, ventilation, and the combination of the two was studied. The alterations in ventilation and perfusion were induced by caval balloon inflation, inflation of the pulmonary artery catheter balloon, and bronchial plugging respectively. MEASUREMENTS AND MAIN RESULTS: The STID technique, with default settings of the intrathoracic blood volume (ITBV) to global end-diastolic volume (GEDV) (i.e., the extrapulmonary intravascular volume between the point of injection of the indicator, and the point of detection) relationship (ITBV = 1.25GEDV), systematically overestimated the EVLW index compared with the gravimetrical method (mean bias of 5.4 mL/kg). By adapting the ITBV to GEDV relationship to the current model (ITBV = 1.52GEDV + 49.7), the accuracy of the STID technique improved. Moreover, the measurement of EVLW(STID) proved to be reduced by manipulation of pulmonary perfusion and ventilation. However, the STID technique could detect an increase in EVLW during endotoxemia independent of the ITBV/GEDV relationship used. CONCLUSION: Despite technological improvement, the dilution techniques for the measurement of EVLW might still be influenced by changes in perfusion and ventilation. The STID technique, in addition, might demand adjustment of the ITBV/GEDV relationship to the particular condition and species subjected to measurement. The STID technique may, however, be a useful tool for monitoring changes of EVLW over time, but further studies are warranted to confirm this.
Authors: Giacomo Baldi; Luna Gargani; Antonio Abramo; Luigia D'Errico; Davide Caramella; Eugenio Picano; Francesco Giunta; Francesco Forfori Journal: Intensive Care Med Date: 2012-09-28 Impact factor: 17.440
Authors: Erik K Hartmann; Bastian Duenges; James E Baumgardner; Klaus Markstaller; Matthias David Journal: Intensive Care Med Date: 2013-04-18 Impact factor: 17.440
Authors: Constantin J C Trepte; Kai A Bachmann; Jan H Stork; Till J Friedheim; Andrea Hinsch; Matthias S Goepfert; Olliver Mann; Jakob R Izbicki; Alwin E Goetz; Daniel A Reuter Journal: Intensive Care Med Date: 2013-01-04 Impact factor: 17.440
Authors: Benjamin Maddison; Riccardo Giudici; Enrico Calzia; Christopher Wolff; Charles Hinds; Peter Radermacher; Rupert M Pearse Journal: Intensive Care Med Date: 2008-07-08 Impact factor: 17.440
Authors: R Blaine Easley; Daniel G Mulreany; Christopher T Lancaster; Jason W Custer; Ana Fernandez-Bustamante; Elizabeth Colantuoni; Brett A Simon Journal: Anesthesiology Date: 2009-11 Impact factor: 7.892
Authors: Benjamin Maddison; Christopher Wolff; George Findlay; Peter Radermacher; Charles Hinds; Rupert M Pearse Journal: Crit Care Date: 2009-07-06 Impact factor: 9.097