BACKGROUND AND PURPOSE: We evaluated the clinical course of 19 acute stroke patients with rapid early improvement of neurological deficit within the 3-hour window, treated with intravenous thrombolytics. RESULTS: No patient demonstrated a neurological deterioration during hospitalization. National Institutes of Health Stroke Scale (NIHSS) scores at therapy decision and discharge were 5 (4 to 6) and 0.5 (0 to 1.5), respectively. At 3-month follow-up, 1 patient had died; in remaining patients, NIHSS was 0 (0 to 1) and modified Rankin Scale 0.5 (0 to 1; < or =1 in 15 patients). CONCLUSIONS: Withholding of intravenous thrombolysis because of spontaneous early regression of neurological symptoms may not be justified.
BACKGROUND AND PURPOSE: We evaluated the clinical course of 19 acute strokepatients with rapid early improvement of neurological deficit within the 3-hour window, treated with intravenous thrombolytics. RESULTS: No patient demonstrated a neurological deterioration during hospitalization. National Institutes of Health Stroke Scale (NIHSS) scores at therapy decision and discharge were 5 (4 to 6) and 0.5 (0 to 1.5), respectively. At 3-month follow-up, 1 patient had died; in remaining patients, NIHSS was 0 (0 to 1) and modified Rankin Scale 0.5 (0 to 1; < or =1 in 15 patients). CONCLUSIONS: Withholding of intravenous thrombolysis because of spontaneous early regression of neurological symptoms may not be justified.
Authors: Joshua Z Willey; Joshua Stillman; Juan A Rivolta; Julio Vieira; Margaret M Doyle; Guillermo Linares; Adrian Marchidann; Mitchell S V Elkind; Bernadette Boden-Albala; Randolph S Marshall Journal: Int J Stroke Date: 2011-11-22 Impact factor: 5.266
Authors: Branko N Huisa; Rema Raman; Will Neil; Karin Ernstrom; Thomas M Hemmen Journal: J Stroke Cerebrovasc Dis Date: 2011-04-30 Impact factor: 2.136