Literature DB >> 16556047

Mitogenic effects of interleukin-8/CXCL8 on cancer cells.

Yong Ming Zhu1, Penella J Woll.   

Abstract

Interleukin (IL)-8 contributes to cancer progression through its multiple functions. Its angiogenic effects are well known, but more recently it has been found to be mitogenic for some cancer cells. Many cancer cells constitutively produce IL-8 and also express the IL-8 receptors, CXCR1 and 2 on the cell membrane. It has been established that IL-8 is an autocrine growth factor for a variety of human cancer cells. The mitogenic effects of IL-8 directly stimulate growth of cancer mass, and it may play a critical role for cancer cells to regrow in metastatic sites.

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Year:  2005        PMID： 16556047     DOI： 10.2217/14796694.1.5.699

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  16 in total

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7.  Production and upregulation of granulocyte chemotactic protein-2/CXCL6 by IL-1beta and hypoxia in small cell lung cancer.

Authors:  Y M Zhu; S M Bagstaff; P J Woll
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8.  Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells.

Authors:  Yong Ming Zhu; Nor Saadah M Azahri; Danny C W Yu; Penella J Woll
Journal:  BMC Cancer       Date:  2008-07-31       Impact factor: 4.430

9.  Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells.

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Journal:  Oncotarget       Date:  2015-04-10

10.  Identification of Key Genes and Pathways in Gefitinib-Resistant Lung Adenocarcinoma using Bioinformatics Analysis.

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Journal:  Evol Bioinform Online       Date:  2021-06-11       Impact factor: 1.625
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