Role of IkappaB kinase in tumorigenesis.

IkappaB kinase plays a central role in regulating NF-kappaB, is a key signaling molecule involved in controlling cell proliferation, survival, antiapoptosis, and tumorigenesis. Alternative pathways can also regulate NF-kappaB in an IkappaB kinase-independent manner. Emerging evidence indicates that IKK phosphorylates and inactivates forkhead box, class O (FOXO)-3a and promotes cell growth and tumorigenesis. Moreover, IKK and NF-kappaB play an important role in linking inflammation and tumorigenesis, and facilitate tumor maintenance and invasion. Thus, IKK and NF-kappaB are promising targets for drug discovery, and agents targeting the IKK/NF-kappaB and FOXO pathways may become therapeutic intervention for those patients with IKK/NF-kappaB-overexpressing cancers in the future.