| Literature DB >> 1655562 |
S R Alberts1, A P Lanier, B J McMahon, A Harpster, L R Bulkow, W L Heyward, C Murray.
Abstract
Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969-1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.Entities:
Mesh:
Year: 1991 PMID: 1655562 DOI: 10.1002/gepi.1370080206
Source DB: PubMed Journal: Genet Epidemiol ISSN: 0741-0395 Impact factor: 2.135