| Literature DB >> 1655554 |
A Itoh1, H Taniguchi, K Sawai, T Takahashi, K Kawamoto, T Deguchi, K Kagawa.
Abstract
It is controversial whether adenomatous hyperplasia (AH) of the liver progresses to hepatocellular carcinoma. We experienced two hepatic lesions in a patient (73-yr-old male) with cirrhotic liver. One was diagnosed as HCC and the other was AH including a small HCC histologically. To investigate cell kinetics and the ploidy pattern of these lesions, Feulgen DNA-cytofluorometry analysis was performed. The result of this analysis suggested that AH developed into extremely well-differentiated HCC composed of mononuclear diploid cells at first and then was further transformed into clear cell type HCC composed of mononuclear tetraploid cells. The development of human HCC, at least in cirrhotic liver, may therefore be a multi-step process.Entities:
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Year: 1991 PMID： 1655554 DOI： 10.1007/bf02782826
Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339