Prophylaxis of uric acid stone in patients with inflammatory bowel disease following extensive colonic resection.

Seven patients (13.0%) among 54 patients with inflammatory bowel disease treated by extensive colonic resection were complicated by renal stone. The mean urinary pH value in cases complicated by renal stones (5.3 +/- 0.4) was significantly lower than among those without stones (6.1 +/- 0.3, P less than 0.01). Sodium bicarbonate (4 gm/day, q.i.d.) was given to 11 patients with renal stones and/or hematuria, whose urinary pH was lower than 5.0 or whose urinary sediments were positive for uric acid crystals since Oct. 1985. Their urinary pH and Na concentration increased significantly and no renal stone complication has been seen in the treated group.