Literature DB >> 1655523

Molecular cloning and mammalian expression of human beta 2-glycoprotein I cDNA.

T Kristensen1, I Schousboe, E Boel, E M Mulvihill, R R Hansen, K B Møller, N P Møller, L Sottrup-Jensen.   

Abstract

Human beta 2-glycoprotein (beta 2gpI) cDNA was isolated from a liver cDNA library and sequenced. The cDNA encoded a 19-residue hydrophobic signal peptide followed by the mature beta 2gpI of 326 amino acid residues. In liver and in the hepatoma cell line HepG2 there are two mRNA species of about 1.4 and 4.3 kb, respectively, hybridizing specifically with the beta 2gpI cDNA. Upon isoelectric focusing, recombinant beta 2gpI obtained from expression of beta 2gpI cDNA in baby hamster kidney cells showed the same pattern of bands as beta 2gpI isolated from plasma, and at least 5 polypeptides were visible.

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Year:  1991        PMID： 1655523     DOI： 10.1016/0014-5793(91)81065-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids.

Authors:  T A Brighton; Y P Dai; P J Hogg; C N Chesterman
Journal:  Biochem J       Date:  1999-05-15       Impact factor: 3.857

2.  Characterization of binding of human beta 2-glycoprotein I to cardiolipin.

Authors:  Z Kertesz; B B Yu; A Steinkasserer; H Haupt; A Benham; R B Sim
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

3.  Biotinylation of glycan chains in beta2 glycoprotein I induces dimerization of the molecule and its detection by the human autoimmune anti-cardiolipin antibody EY2C9.

Authors:  Arnaud Dupuy D'Angeac; Ilias Stefas; Hubert Graafland; Frédéric De Lamotte; Marcel Rucheton; Caroline Palais; Anna-Karin Eriksson; Priscille Bosc; Caroline Rosé; Robert Chicheportiche
Journal:  Biochem J       Date:  2006-01-01       Impact factor: 3.857

4.  β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model.

Authors:  Ariela Arad; Valerie Proulle; Richard A Furie; Barbara C Furie; Bruce Furie
Journal:  Blood       Date:  2011-01-18       Impact factor: 22.113

5.  beta2-glycoprotein i is a cofactor for tissue plasminogen activator-mediated plasminogen activation.

Authors:  Chunya Bu; Lei Gao; Weidong Xie; Jainwei Zhang; Yuhong He; Guoping Cai; Keith R McCrae
Journal:  Arthritis Rheum       Date:  2009-02

6.  Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I.

Authors:  Paolo Durigutto; Paolo Macor; Nicola Pozzi; Chiara Agostinis; Fleur Bossi; Pier Luigi Meroni; Claudia Grossi; Maria O Borghi; William Planer; Peter Garred; Francesco Tedesco
Journal:  J Immunol       Date:  2020-08-05       Impact factor: 5.422

7.  Recombinant hepatitis B surface antigen and anionic phospholipids share a binding region in the fifth domain of beta2-glycoprotein I (apolipoprotein H).

Authors:  Haider Mehdi; Asma Naqvi; M Ilyas Kamboh
Journal:  Biochim Biophys Acta       Date:  2008-01-12

8.  Apolipoprotein H promoter polymorphisms in relation to lupus and lupus-related phenotypes.

Authors:  Sangita Suresh; F Yesim K Demirci; Erin Jacobs; Amy H Kao; Elisa Y Rhew; Dharambir K Sanghera; Faith Selzer; Kim Sutton-Tyrrell; David McPherson; Franklin A Bontempo; Candace M Kammerer; Rosalind Ramsey-Goldman; Susan Manzi; M Ilyas Kamboh
Journal:  J Rheumatol       Date:  2009-02       Impact factor: 4.666

9.  Cloning and characterization of the human beta2-glycoprotein I (beta2-GPI) gene promoter: roles of the atypical TATA box and hepatic nuclear factor-1alpha in regulating beta2-GPI promoter activity.

Authors:  Hsueh-Hsiao Wang; An-Na Chiang
Journal:  Biochem J       Date:  2004-06-01       Impact factor: 3.857

10.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-06-25       Impact factor: 16.971
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