Literature DB >> 1655474

Intracerebroventricular pertussis toxin enhances sensitivity to N-methyl-D-aspartate-induced seizures in mice.

M J Durcan1, P F Morgan.   

Abstract

The effect of pretreatment with pertussis toxin on N-methyl-D-aspartate (NMDA)-induced seizures was investigated in mice. In animals treated with pertussis toxin (0.5 micrograms/animal i.c.v) five days prior to testing the convulsant ED50 of NMDA was calculated to be 18 mg/kg whereas it was calculated to be 107 mg/kg in sham-treated animals. These results suggest the pertussis toxin enhances sensitivity to NMDA, possibly via its actions on inhibitory G-proteins.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1655474     DOI： 10.1016/0014-2999(91)90523-s

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin.

Authors:  Salvador Castaneda Vega; Veronika Leiss; Roland Piekorz; Carsten Calaminus; Katja Pexa; Marta Vuozzo; Andreas M Schmid; Vasudharani Devanathan; Christian Kesenheimer; Bernd J Pichler; Sandra Beer-Hammer; Bernd Nürnberg
Journal:  J Mol Med (Berl)       Date:  2019-12-06       Impact factor: 4.599

2.  Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.

Authors:  D K Von Lubitz; R C Lin; N Melman; X D Ji; M F Carter; K A Jacobson
Journal:  Eur J Pharmacol       Date:  1994-04-21       Impact factor: 4.432

3.  The Potential Role of Subclinical Bordetella pertussis Infection in Epilepsy.

Authors:  Keith Rubin; Steven Glazer
Journal:  Front Cell Infect Microbiol       Date:  2019-08-28       Impact factor: 5.293
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.