BACKGROUND: We hypothesized that fibrinogen, as a marker of chronic inflammation, is inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) in healthy persons. METHODS: The CARDIA cohort started in 1985 and included black and white men and women, aged 18-30, from the general population. Spirometry testing conducted at years 5 and 10 [FVC, FEV(1), and their ratio (FEV(1)/FVC)] was studied relative to plasma fibrinogen levels measured at year 5 (cross-sectional n = 4,040) and at year 7 (longitudinal n = 3,001), controlling for race, sex, age, height, smoking, asthma, body mass index, physical activity, birth control pill use, and alcohol intake. RESULTS: In cross-sectional analyses, FVC at year 5 was lower by 166 ml (95% confidence interval 116-216 ml) in the highest vs lowest year 5 fibrinogen quartile. At year 10, holding year 5 FVC and change in fibrinogen (year 7-year 5) constant, the difference in FVC between the highest and the lowest year 5 fibrinogen quartiles widened by 67 ml (95% CI 31-103 ml). The corresponding differences for FEV(1) were 166 ml (95% CI 146-253 ml) at year 5 and 45 ml (95% CI 11-80 ml) widening by year 10. The FEV(1)/FVC ratio was unrelated to plasma fibrinogen. CONCLUSION: These findings are consistent with the hypothesis that fibrinogen, possibly as a marker for chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.
BACKGROUND: We hypothesized that fibrinogen, as a marker of chronic inflammation, is inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) in healthy persons. METHODS: The CARDIA cohort started in 1985 and included black and white men and women, aged 18-30, from the general population. Spirometry testing conducted at years 5 and 10 [FVC, FEV(1), and their ratio (FEV(1)/FVC)] was studied relative to plasma fibrinogen levels measured at year 5 (cross-sectional n = 4,040) and at year 7 (longitudinal n = 3,001), controlling for race, sex, age, height, smoking, asthma, body mass index, physical activity, birth control pill use, and alcohol intake. RESULTS: In cross-sectional analyses, FVC at year 5 was lower by 166 ml (95% confidence interval 116-216 ml) in the highest vs lowest year 5 fibrinogen quartile. At year 10, holding year 5 FVC and change in fibrinogen (year 7-year 5) constant, the difference in FVC between the highest and the lowest year 5 fibrinogen quartiles widened by 67 ml (95% CI 31-103 ml). The corresponding differences for FEV(1) were 166 ml (95% CI 146-253 ml) at year 5 and 45 ml (95% CI 11-80 ml) widening by year 10. The FEV(1)/FVC ratio was unrelated to plasma fibrinogen. CONCLUSION: These findings are consistent with the hypothesis that fibrinogen, possibly as a marker for chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.
Authors: Jennifer Weuve; M Maria Glymour; Howard Hu; David Sparrow; Avron Spiro; Pantel S Vokonas; Augusto A Litonjua Journal: J Am Geriatr Soc Date: 2011-06-30 Impact factor: 5.562
Authors: David R Jacobs; Hiroshi Yatsuya; Mary O Hearst; Bharat Thyagarajan; Ravi Kalhan; Sharon Rosenberg; Lewis J Smith; R Graham Barr; Daniel A Duprez Journal: Hypertension Date: 2011-12-27 Impact factor: 10.190
Authors: Pengcheng Xun; Kiang Liu; J Steven Morris; Martha L Daviglus; June Stevens; David R Jacobs; Ka He Journal: Am J Epidemiol Date: 2010-03-10 Impact factor: 4.897
Authors: Ravi Kalhan; Betty T Tran; Laura A Colangelo; Sharon R Rosenberg; Kiang Liu; Bharat Thyagarajan; David R Jacobs; Lewis J Smith Journal: PLoS One Date: 2010-07-02 Impact factor: 3.240
Authors: Andrew W Fogarty; Sarah A Lewis; Tricia M McKeever; Gordon D O Lowe; Lorna Clark; John Britton Journal: PLoS One Date: 2010-11-16 Impact factor: 3.240
Authors: Daniel A Duprez; Mary O Hearst; Pamela L Lutsey; David M Herrington; Pamela Ouyang; R Graham Barr; David A Bluemke; David McAllister; J Jeffrey Carr; David R Jacobs Journal: Hypertension Date: 2013-01-02 Impact factor: 10.190