| Literature DB >> 16554152 |
James P Guare1, John S Wai, Robert P Gomez, Neville J Anthony, Samson M Jolly, Amanda R Cortes, Joseph P Vacca, Peter J Felock, Kara A Stillmock, William A Schleif, Gregory Moyer, Lori J Gabryelski, Lixia Jin, I-Wu Chen, Daria J Hazuda, Steven D Young.
Abstract
A series of 5-amino derivatives of 8-hydroxy[1,6]-naphthyridine-7-carboxamide exhibiting sub-micromolar potency against replication of HIV-1 in cell culture was identified. One of these analogs, compound 12, displayed excellent pharmacokinetic properties when dosed orally in rats and in monkeys. This compound was demonstrated to be efficacious against replication of simian-human immunodeficiency virus (SHIV) 89.6P in infected rhesus macaques.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16554152 DOI： 10.1016/j.bmcl.2006.03.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823