Literature DB >> 1655278

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.

A Szabo1, J Dalmau, G Manley, M Rosenfeld, E Wong, J Henson, J B Posner, H M Furneaux.   

Abstract

A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.

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Year:  1991        PMID： 1655278     DOI： 10.1016/0092-8674(91)90184-z

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  144 in total

1.  Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.

Authors:  G E Aranda-Abreu; L Behar; S Chung; H Furneaux; I Ginzburg
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

2.  Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.

Authors:  A O Güre; E Stockert; M J Scanlan; R S Keresztes; D Jäger; N K Altorki; L J Old; Y T Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

3.  HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation.

Authors:  W Wang; M C Caldwell; S Lin; H Furneaux; M Gorospe
Journal:  EMBO J       Date:  2000-05-15       Impact factor: 11.598

4.  HuR regulates p21 mRNA stabilization by UV light.

Authors:  W Wang; H Furneaux; H Cheng; M C Caldwell; D Hutter; Y Liu; N Holbrook; M Gorospe
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

Review 5.  Immunological mechanisms in paraneoplastic peripheral neuropathy.

Authors:  J C Antoine
Journal:  Clin Rev Allergy Immunol       Date:  2000-08       Impact factor: 8.667

6.  The identification of an endonuclease that cleaves within an HuR binding site in mRNA.

Authors:  Z Zhao; F C Chang; H M Furneaux
Journal:  Nucleic Acids Res       Date:  2000-07-15       Impact factor: 16.971

7.  Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis.

Authors:  E M Tan
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

8.  The RNA-binding protein HuD is required for GAP-43 mRNA stability, GAP-43 gene expression, and PKC-dependent neurite outgrowth in PC12 cells.

Authors:  C D Mobarak; K D Anderson; M Morin; A Beckel-Mitchener; S L Rogers; H Furneaux; P King; N I Perrone-Bizzozero
Journal:  Mol Biol Cell       Date:  2000-09       Impact factor: 4.138

9.  Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins.

Authors:  Katsumi Kasashima; Eiji Sakashita; Kuniaki Saito; Hiroshi Sakamoto
Journal:  Nucleic Acids Res       Date:  2002-10-15       Impact factor: 16.971

10.  Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system.

Authors:  Yoshihiro Konishi; Kristina Lindholm; Li-Bang Yang; Rena Li; Yong Shen
Journal:  Am J Pathol       Date:  2002-11       Impact factor: 4.307
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