Literature DB >> 16552423

Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable15O-O2.

Takashi Temma1, Yasuhiro Magata, Yuji Kuge, Sayaka Shimonaka, Kohei Sano, Yumiko Katada, Hidekazu Kawashima, Takahiro Mukai, Hiroshi Watabe, Hidehiro Iida, Hideo Saji.   

Abstract

The threshold of cerebral blood flow (CBF) into infarction in rats has been indicated to be similar to that in patients. However, CBF does not reflect metabolic function, and so estimations of oxygen metabolism have been required. Here, we estimated changes in oxygen metabolism after occluding the right middle cerebral artery (MCA) in rats using an injectable (15)O-O(2) we developed. A decrease in CBF (left: 0.67+/-0.22 mL/min/g, right: 0.44+/-0.17 mL/min/g, P<0.05) and compensatory increase in the oxygen extraction fraction (OEF) (left: 0.42+/-0.13, right: 0.50+/-0.19, P<0.05) were observed at 1-h after occlusion. In contrast, a marked decrease in CBF and the cerebral metabolic rate for oxygen and a collapse of the compensatory OEF mechanism were found at 24 h after occlusion. Injectable (15)O-O(2) could be used to reliably estimate oxygen metabolism in an infarction rat model with positron emission tomography.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16552423     DOI： 10.1038/sj.jcbfm.9600302

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  7 in total

1.  Cerebral oxygen metabolism of rats using injectable (15)O-oxygen with a steady-state method.

Authors:  Masato Kobayashi; Tetsuya Mori; Yasushi Kiyono; Vijay Narayan Tiwari; Rikiya Maruyama; Keiichi Kawai; Hidehiko Okazawa
Journal:  J Cereb Blood Flow Metab       Date:  2011-08-24       Impact factor: 6.200

2.  Oxygen metabolism MRI - A comparison with perfusion imaging in a rat model of MCA branch occlusion and reperfusion.

Authors:  Philip V Little; Sandra E Kraft; Arvin Chireh; Peter Damberg; Staffan Holmin
Journal:  J Cereb Blood Flow Metab       Date:  2019-12-16       Impact factor: 6.200

3.  Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis.

Authors:  Takashi Temma; Makoto Yamazaki; Jun Miyanohara; Hisashi Shirakawa; Naoya Kondo; Kazuhiro Koshino; Shuji Kaneko; Hidehiro Iida
Journal:  J Cereb Blood Flow Metab       Date:  2017-02-09       Impact factor: 6.200

4.  Development of an H(2)(15)O steady-state method combining a bolus and slow increasing injection with a multiprogramming syringe pump.

Authors:  Masato Kobayashi; Yasushi Kiyono; Rikiya Maruyama; Tetsuya Mori; Keiichi Kawai; Hidehiko Okazawa
Journal:  J Cereb Blood Flow Metab       Date:  2010-07-28       Impact factor: 6.200

5.  Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable (15)O-O (2).

Authors:  Takashi Temma; Hidehiro Iida; Takuya Hayashi; Noboru Teramoto; Youichiro Ohta; Nobuyuki Kudomi; Hiroshi Watabe; Hideo Saji; Yasuhiro Magata
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-09-04       Impact factor: 9.236

6.  Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia.

Authors:  Phill B Jones; Hwa Kyoung Shin; David A Boas; Bradley T Hyman; Michael A Moskowitz; Cenk Ayata; Andrew K Dunn
Journal:  J Biomed Opt       Date:  2008 Jul-Aug       Impact factor: 3.170

Review 7.  PET quantification of cerebral oxygen metabolism in small animals.

Authors:  Takashi Temma; Kazuhiro Koshino; Tetsuaki Moriguchi; Jun-ichiro Enmi; Hidehiro Iida
Journal:  ScientificWorldJournal       Date:  2014-08-17
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.