Lisa Licitra1, Chiara Rossini, Paolo Bossi, Laura D Locati. 1. Head and Neck Cancer Medical Oncology Unit, Cancer Medicine Department, Istituto Nazionale Tumori, Milan, Italy. lisa.licitra@istitutotumori.mi.it
Abstract
PURPOSE OF REVIEW: Recent cumulated evidence suggests that factors other than those conventionally known may contribute to the development of head and neck cancer. In fact, a review of the most recent literature shows interesting advances in molecular epidemiology. RECENT FINDINGS: Recent studies have pointed out the role both of exposure to carcinogens and of an inherited or acquired genetic susceptibility. A very broad mechanism by which gene families can be responsible for the disease has been depicted. This mechanism ranges from behaviour genes, which can regulate lifestyle habits, to metabolizing genes, DNA repair genes and cell cycle control genes. SUMMARY: This review tries to summarize the most recent advances in the field of cancerogenesis in head and neck cancer.
PURPOSE OF REVIEW: Recent cumulated evidence suggests that factors other than those conventionally known may contribute to the development of head and neck cancer. In fact, a review of the most recent literature shows interesting advances in molecular epidemiology. RECENT FINDINGS: Recent studies have pointed out the role both of exposure to carcinogens and of an inherited or acquired genetic susceptibility. A very broad mechanism by which gene families can be responsible for the disease has been depicted. This mechanism ranges from behaviour genes, which can regulate lifestyle habits, to metabolizing genes, DNA repair genes and cell cycle control genes. SUMMARY: This review tries to summarize the most recent advances in the field of cancerogenesis in head and neck cancer.
Authors: Manchao Zhang; Bhavna Kumar; Longzhu Piao; Xiujie Xie; Alessandra Schmitt; Nicole Arradaza; Michael Cippola; Matthew Old; Amit Agrawal; Enver Ozer; David E Schuller; Theodoros N Teknos; Quintin Pan Journal: Cancer Date: 2013-12-30 Impact factor: 6.860
Authors: Valerio Vitelli; Paolo Falvo; Solomon G Nergadze; Marco Santagostino; Lela Khoriauli; Paola Pellanda; Giulia Bertino; Antonio Occhini; Marco Benazzo; Patrizia Morbini; Marco Paulli; Camillo Porta; Elena Giulotto Journal: Int J Mol Sci Date: 2018-01-17 Impact factor: 5.923