Literature DB >> 16552185

Akt1 in endothelial cell and angiogenesis.

Payaningal R Somanath1, Olga V Razorenova, Juhua Chen, Tatiana V Byzova.   

Abstract

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.

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Year:  2006        PMID： 16552185      PMCID： PMC1569947          DOI： 10.4161/cc.5.5.2538

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  72 in total

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Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

4.  Phosphorylation sites in the integrin beta3 cytoplasmic domain in intact platelets.

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5.  Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.

Authors:  Carsten Skurk; Henrike Maatz; Edward Rocnik; Ann Bialik; Thomas Force; Kenneth Walsh
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6.  Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner.

Authors:  Y Fujio; K Walsh
Journal:  J Biol Chem       Date:  1999-06-04       Impact factor: 5.157

7.  Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice.

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Authors:  Jing Fang; Chang Xia; Zongxian Cao; Jenny Z Zheng; Eddie Reed; Bing-Hua Jiang
Journal:  FASEB J       Date:  2005-03       Impact factor: 5.191

9.  Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.

Authors:  H P Gerber; A McMurtrey; J Kowalski; M Yan; B A Keyt; V Dixit; N Ferrara
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10.  Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP.

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Journal:  J Cell Biol       Date:  2004-11-22       Impact factor: 10.539
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  116 in total

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Journal:  Stem Cell Rev Rep       Date:  2013-06       Impact factor: 5.739

2.  Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes.

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3.  Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia.

Authors:  Tao Wang; Alexis Cunningham; Ayotunde O Dokun; Surovi Hazarika; Kevin Houston; Lingdan Chen; R John Lye; Rosanne Spolski; Warren J Leonard; Brian H Annex
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4.  Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway.

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-31       Impact factor: 11.205

5.  Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells.

Authors:  Chohreh Partovian; Rong Ju; Zhen W Zhuang; Kathleen A Martin; Michael Simons
Journal:  Mol Cell       Date:  2008-10-10       Impact factor: 17.970

6.  Gene Expression Profile of Vascular Endothelial Growth Factors (VEGFs) and Platelet-derived Growth Factors (PDGFs) in the Normal Cornea.

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7.  Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.

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8.  14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly.

Authors:  Payaningal R Somanath; Tatiana V Byzova
Journal:  J Cell Physiol       Date:  2009-02       Impact factor: 6.384

9.  Molecular mechanisms underlying the anti-proliferative and anti-migratory effects of folate on homocysteine-challenged rat aortic smooth muscle cells.

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10.  Piperine, a dietary phytochemical, inhibits angiogenesis.

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