Literature DB >> 1655141

GABAA receptors are differentially sensitive to zinc: dependence on subunit composition.

T G Smart1, S J Moss, X Xie, R L Huganir.   

Abstract

GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the gamma subunit were inhibited by zinc. Embryonic neurons also exhibited zinc-sensitive GABA responses, in contrast to adult neurones. This developmentally-sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the gamma subunit.

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Year:  1991        PMID： 1655141      PMCID： PMC1908216          DOI： 10.1111/j.1476-5381.1991.tb12337.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands.

Authors:  P Malherbe; A Draguhn; G Multhaup; K Beyreuther; H Möhler
Journal:  Brain Res Mol Brain Res       Date:  1990-08

Review 2.  Uncultured lobster muscle, cultured neurons and brain slices: the neurophysiology of zinc.

Authors:  T G Smart
Journal:  J Pharm Pharmacol       Date:  1990-06       Impact factor: 3.765

3.  Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in Xenopus oocytes.

Authors:  E S Levitan; L A Blair; V E Dionne; E A Barnard
Journal:  Neuron       Date:  1988-11       Impact factor: 17.173

4.  Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons.

Authors:  G L Westbrook; M L Mayer
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

5.  Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties.

Authors:  S J Moss; T G Smart; N M Porter; N Nayeem; J Devine; F A Stephenson; R L Macdonald; E A Barnard
Journal:  Eur J Pharmacol       Date:  1990-07-31       Impact factor: 4.432

6.  Functional properties of recombinant rat GABAA receptors depend upon subunit composition.

Authors:  T A Verdoorn; A Draguhn; S Ymer; P H Seeburg; B Sakmann
Journal:  Neuron       Date:  1990-06       Impact factor: 17.173

7.  Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.

Authors:  D B Pritchett; H Sontheimer; B D Shivers; S Ymer; H Kettenmann; P R Schofield; P H Seeburg
Journal:  Nature       Date:  1989-04-13       Impact factor: 49.962

8.  Differential effect of zinc on the vertebrate GABAA-receptor complex.

Authors:  T G Smart; A Constanti
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

9.  Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+.

Authors:  A Draguhn; T A Verdorn; M Ewert; P H Seeburg; B Sakmann
Journal:  Neuron       Date:  1990-12       Impact factor: 17.173

10.  Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.

Authors:  P Kofuji; J B Wang; S J Moss; R L Huganir; D R Burt
Journal:  J Neurochem       Date:  1991-02       Impact factor: 5.372
  10 in total
  71 in total

1.  Two gamma2L subunit domains confer low Zn2+ sensitivity to ternary GABA(A) receptors.

Authors:  N Nagaya; R L Macdonald
Journal:  J Physiol       Date:  2001-04-01       Impact factor: 5.182

2.  Modulation of glycine receptors in retinal ganglion cells by zinc.

Authors:  Y Han; S M Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

3.  Modulation of neuronal and recombinant GABAA receptors by redox reagents.

Authors:  A Amato; C N Connolly; S J Moss; T G Smart
Journal:  J Physiol       Date:  1999-05-15       Impact factor: 5.182

4.  A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

Authors:  T G Smart
Journal:  J Physiol       Date:  1992-02       Impact factor: 5.182

5.  Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants.

Authors:  Paul S Miller; Robert J Harvey; Trevor G Smart
Journal:  Br J Pharmacol       Date:  2004-08-09       Impact factor: 8.739

6.  Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.

Authors:  Hong-Jin Shu; John Bracamontes; Amanda Taylor; Kyle Wu; Megan M Eaton; Gustav Akk; Brad Manion; Alex S Evers; Kathiresan Krishnan; Douglas F Covey; Charles F Zorumski; Joe Henry Steinbach; Steven Mennerick
Journal:  Br J Pharmacol       Date:  2012-04       Impact factor: 8.739

7.  Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy.

Authors:  Siegward-M Elsas; Saman Hazany; William L Gregory; Istvan Mody
Journal:  Epilepsia       Date:  2009-01-26       Impact factor: 5.864

8.  Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.

Authors:  Zuzana Dostalova; Xiaojuan Zhou; Aiping Liu; Xi Zhang; Yinghui Zhang; Rooma Desai; Stuart A Forman; Keith W Miller
Journal:  Protein Sci       Date:  2013-12-16       Impact factor: 6.725

9.  Cationic modulation of rho 1-type gamma-aminobutyrate receptors expressed in Xenopus oocytes.

Authors:  D J Calvo; A E Vazquez; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

10.  Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons.

Authors:  Benjamin K Lau; Shafinaz Karim; Ann K Goodchild; Christopher W Vaughan; Geoffrey M Drew
Journal:  Br J Pharmacol       Date:  2014-06       Impact factor: 8.739
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