AIM: The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche. METHODS: The insulin sensitivity index was calculated from the frequently sampled intravenous glucose tolerance test with tolbutamide. Thirty-five prepubertal girls (23 Caribbean-Hispanic and 12 African-American; mean age 6.8 years) were studied. The insulin sensitivity index was compared to birth weight, body mass index (BMI), the presence of acanthosis nigricans (AN), insulin-like growth factor 1, insulin-like growth factor binding protein 1, sex hormone binding globulin, lipid profile, and adrenocorticotropic hormone stimulated androgens. RESULTS: The best prediction models included birth weight, BMI, and AN (model 1: R(2) = 0.78) and BMI, AN, and serum 17-OH pregnenolone (model 2: R(2) = 0.76). When viewed as screening tests, a cutoff value <5.5 (premature adrenarche insulin resistance score) in both equations showed a sensitivity of 100% and a specificity of 85%. CONCLUSION: Born small for gestational age, premature adrenarche, obesity, AN, and higher serum 17-OH pregnenolone levels may confer negative, but independent, health risks. Copyright (c) 2006 S. Karger AG, Basel.
AIM: The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche. METHODS: The insulin sensitivity index was calculated from the frequently sampled intravenous glucose tolerance test with tolbutamide. Thirty-five prepubertal girls (23 Caribbean-Hispanic and 12 African-American; mean age 6.8 years) were studied. The insulin sensitivity index was compared to birth weight, body mass index (BMI), the presence of acanthosis nigricans (AN), insulin-like growth factor 1, insulin-like growth factor binding protein 1, sex hormone binding globulin, lipid profile, and adrenocorticotropic hormone stimulated androgens. RESULTS: The best prediction models included birth weight, BMI, and AN (model 1: R(2) = 0.78) and BMI, AN, and serum 17-OH pregnenolone (model 2: R(2) = 0.76). When viewed as screening tests, a cutoff value <5.5 (premature adrenarche insulin resistance score) in both equations showed a sensitivity of 100% and a specificity of 85%. CONCLUSION: Born small for gestational age, premature adrenarche, obesity, AN, and higher serum 17-OH pregnenolone levels may confer negative, but independent, health risks. Copyright (c) 2006 S. Karger AG, Basel.
Authors: Steven M Kymes; Dennis L Lambert; Paul P Lee; David C Musch; Carla J Siegfried; Sameer V Kotak; Dustin L Stwalley; Joel Fain; Chris Johnson; Mae O Gordon Journal: Ophthalmology Date: 2012-04-25 Impact factor: 12.079
Authors: Rita Santos-Silva; Manuel Fontoura; João T Guimarães; Henrique Barros; Ana Cristina Santos Journal: Pediatr Res Date: 2021-08-20 Impact factor: 3.953
Authors: Ai Kubo; Assiamira Ferrara; Cecile A Laurent; Gayle C Windham; Louise C Greenspan; Julianna Deardorff; Robert A Hiatt; Charles P Quesenberry; Lawrence H Kushi Journal: Am J Epidemiol Date: 2016-06-07 Impact factor: 4.897