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Literature DB >> 16549768

The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors.

Corey M McCann¹, John Bracamontes, Joe Henry Steinbach, Joshua R Sanes.

Abstract

The polypeptide snake toxin alpha-bungarotoxin (BTX) has been used in hundreds of studies on the structure, function, and development of the neuromuscular junction because it binds tightly and specifically to the nicotinic acetylcholine receptors (nAChRs) at this synapse. We show here that BTX also binds to and blocks a subset of GABA(A) receptors (GABA(A)Rs) that contain the GABA(A)R beta3 subunit. These results introduce a previously unrecognized tool for analysis of GABA(A)Rs but may complicate interpretation of some studies on neuronal nAChRs.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 16549768 PMCID： PMC1458809 DOI： 10.1073/pnas.0600847103

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

1. Chimeric analysis of a neuronal nicotinic acetylcholine receptor reveals amino acids conferring sensitivity to alpha-bungarotoxin.

Authors: M M Levandoski; Y Lin; L Moise; J T McLaughlin; E Cooper; E Hawrot
Journal: J Biol Chem Date: 1999-09-10 Impact factor: 5.157

Review 2. Development of the vertebrate neuromuscular junction.

Authors: J R Sanes; J W Lichtman
Journal: Annu Rev Neurosci Date: 1999 Impact factor: 12.449

3. Subunit arrangement of gamma-aminobutyric acid type A receptors.

Authors: S W Baumann; R Baur; E Sigel
Journal: J Biol Chem Date: 2001-07-20 Impact factor: 5.157

4. Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides.

Authors: Martha Marinou; Socrates J Tzartos
Journal: Biochem J Date: 2003-06-01 Impact factor: 3.857

5. Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins.

Authors: Hideki Kawai; Wagner Zago; Darwin K Berg
Journal: J Neurosci Date: 2002-09-15 Impact factor: 6.167

Review 6. Subunit composition, distribution and function of GABA(A) receptor subtypes.

Authors: W Sieghart; G Sperk
Journal: Curr Top Med Chem Date: 2002-08 Impact factor: 3.295

7. Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.

Authors: Sabine W Baumann; Roland Baur; Erwin Sigel
Journal: J Biol Chem Date: 2002-09-24 Impact factor: 5.157

Review 8. Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost.

Authors: Terrance T Kummer; Thomas Misgeld; Joshua R Sanes
Journal: Curr Opin Neurobiol Date: 2005-12-28 Impact factor: 6.627

9. Peptide tags for labeling membrane proteins in live cells with multiple fluorophores.

Authors: Corey M McCann; Florence M Bareyre; Jeff W Lichtman; Joshua R Sanes
Journal: Biotechniques Date: 2005-06 Impact factor: 1.993

10. Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus.

Authors: R Fabian-Fine; P Skehel; M L Errington; H A Davies; E Sher; M G Stewart; A Fine
Journal: J Neurosci Date: 2001-10-15 Impact factor: 6.167

21 in total

1. Traumatic brain injury elicits similar alterations in α7 nicotinic receptor density in two different experimental models.

Authors: Peter-Georg Hoffmeister; Cornelius K Donat; Martin U Schuhmann; Cornelia Voigt; Bernd Walter; Karen Nieber; Jürgen Meixensberger; Reinhard Bauer; Peter Brust
Journal: Neuromolecular Med Date: 2010-09-21 Impact factor: 3.843

2. Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

Authors: Denis S Kudryavtsev; Irina V Shelukhina; Lina V Son; Lucy O Ojomoko; Elena V Kryukova; Ekaterina N Lyukmanova; Maxim N Zhmak; Dmitry A Dolgikh; Igor A Ivanov; Igor E Kasheverov; Vladislav G Starkov; Joachim Ramerstorfer; Werner Sieghart; Victor I Tsetlin; Yuri N Utkin
Journal: J Biol Chem Date: 2015-07-28 Impact factor: 5.157

The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors.

1. Chimeric analysis of a neuronal nicotinic acetylcholine receptor reveals amino acids conferring sensitivity to alpha-bungarotoxin.

Review 2. Development of the vertebrate neuromuscular junction.

3. Subunit arrangement of gamma-aminobutyric acid type A receptors.

4. Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides.

5. Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins.

Review 6. Subunit composition, distribution and function of GABA(A) receptor subtypes.

7. Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.

Review 8. Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost.

9. Peptide tags for labeling membrane proteins in live cells with multiple fluorophores.

10. Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus.

1. Traumatic brain injury elicits similar alterations in α7 nicotinic receptor density in two different experimental models.

2. Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

3. Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts.

4. Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.

5. MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.

6. BDNF up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons.

7. Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.

8. In vivo imaging of presynaptic terminals and postsynaptic sites in the mouse submandibular ganglion.

9. Proteomic Investigation of Murine Neuronal α7-Nicotinic Acetylcholine Receptor Interacting Proteins.

10. GABAA receptor membrane insertion rates are specified by their subunit composition.