Literature DB >> 16549325

Molecular pathogenesis of pancreatic cancer.

Anirban Maitra1, Scott E Kern, Ralph H Hruban.   

Abstract

Pancreatic cancer is fundamentally a disease of inherited and acquired mutations in cancer-related genes. The genes targeted in pancreatic cancer include tumor-suppressor genes (p16/CDKN2A, TP53 and SMAD4), oncogenes (KRAS, BRAF, AKT2, MYB, and AIB1), and genome-maintenance genes (MLH1, MSH2, BRAC2 and other Fanconi anemia genes). An understanding of the cancer-related genes that are altered in pancreatic cancer has a number of clinical applications including genetic counseling for individuals with a family history of cancer, early detection of pancreatic neoplasia, and mechanism-based therapies for patients with advanced disease. This chapter will provide an overview of the molecular pathogenesis of pancreatic cancer with emphasis on clinical applications.

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Year:  2006        PMID： 16549325     DOI： 10.1016/j.bpg.2005.10.002

Source DB:  PubMed          Journal:  Best Pract Res Clin Gastroenterol        ISSN： 1521-6918            Impact factor:   3.043


  73 in total

1.  A case of synchronous pancreatic ductal adenocarcinoma and ovarian mucinous cystic neoplasm: use of kras mutation molecular phenotyping to demonstrate independent primary origin.

Authors:  Maeve Lowery; David Klimstra; Cyrus Hedvat; William Jarnagin; Dennis Chi; Eileen M O'Reilly
Journal:  Gastrointest Cancer Res       Date:  2012-03

2.  Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Authors:  Meredith A Morgan; Leslie A Parsels; Lili Zhao; Joshua D Parsels; Mary A Davis; Maria C Hassan; Sankari Arumugarajah; Linda Hylander-Gans; Deborah Morosini; Diane M Simeone; Christine E Canman; Daniel P Normolle; Sonya D Zabludoff; Jonathan Maybaum; Theodore S Lawrence
Journal:  Cancer Res       Date:  2010-05-25       Impact factor: 12.701

3.  Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.

Authors:  Veena Sangwan; Sulagna Banerjee; Kelsey M Jensen; Zhiyu Chen; Rohit Chugh; Vikas Dudeja; Selwyn M Vickers; Ashok K Saluja
Journal:  Pancreas       Date:  2015-05       Impact factor: 3.327

4.  Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.

Authors:  Pierre-Paul Prévot; Alexandru Simion; Adrien Grimont; Marta Colletti; Abed Khalaileh; Géraldine Van den Steen; Christine Sempoux; Xiaobo Xu; Véronique Roelants; Jacob Hald; Luc Bertrand; Harry Heimberg; Stephen F Konieczny; Yuval Dor; Frédéric P Lemaigre; Patrick Jacquemin
Journal:  Gut       Date:  2012-01-22       Impact factor: 23.059

5.  A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.

Authors:  Bincy Philip; Christina L Roland; Jaroslaw Daniluk; Yan Liu; Deyali Chatterjee; Sobeyda B Gomez; Baoan Ji; Haojie Huang; Huamin Wang; Jason B Fleming; Craig D Logsdon; Zobeida Cruz-Monserrate
Journal:  Gastroenterology       Date:  2013-08-16       Impact factor: 22.682

6.  Telomere length and pancreatic cancer: a case-control study.

Authors:  Halcyon G Skinner; Ronald E Gangnon; Kristin Litzelman; Ruth A Johnson; Suresh T Chari; Gloria M Petersen; Lisa A Boardman
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-10-23       Impact factor: 4.254

7.  DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease.

Authors:  Mansour A Parsi; Ang Li; Chung-Pin Li; Michael Goggins
Journal:  Clin Gastroenterol Hepatol       Date:  2008-09-05       Impact factor: 11.382

Review 8.  Pancreatic carcinogenesis.

Authors:  Jan-Bart M Koorstra; Steven R Hustinx; G Johan A Offerhaus; Anirban Maitra
Journal:  Pancreatology       Date:  2008-04-01       Impact factor: 3.996

9.  Mitochondrial DNA mutations in pancreatic cancer.

Authors:  Keyanoosh Kassauei; Nils Habbe; Michael E Mullendore; Collins A Karikari; Anirban Maitra; Georg Feldmann
Journal:  Int J Gastrointest Cancer       Date:  2006

Review 10.  Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs).

Authors:  Jan-Bart M Koorstra; Georg Feldmann; Nils Habbe; Anirban Maitra
Journal:  Langenbecks Arch Surg       Date:  2008-02-19       Impact factor: 3.445
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