BACKGROUND/ PURPOSE: This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation. METHODS: Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation. RESULTS: Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5-year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%). CONCLUSIONS: Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living-donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.
BACKGROUND/ PURPOSE: This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation. METHODS: Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation. RESULTS:Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5-year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%). CONCLUSIONS: Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living-donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.
Authors: Nicolas Golse; Simone Santoni; Vincent Karam; Oriana Ciacio; Gabriella Pittau; Marc-Antoine Allard; Daniel Cherqui; Antonio Sa Cunha; René Adam; Denis Castaing; Eric Vibert Journal: World J Surg Date: 2018-05 Impact factor: 3.352
Authors: C E Freise; B W Gillespie; A J Koffron; A S F Lok; T L Pruett; J C Emond; J H Fair; R A Fisher; K M Olthoff; J F Trotter; R M Ghobrial; J E Everhart Journal: Am J Transplant Date: 2008-10-24 Impact factor: 8.086
Authors: Iago Justo; Carlos Jiménez-Romero; Alejandro Manrique; Oscar Caso; Jorge Calvo; Felix Cambra; Alberto Marcacuzco Journal: World J Surg Date: 2018-10 Impact factor: 3.352
Authors: Alice Tung Wan Song; Vivian Iida Avelino-Silva; Rafael Antonio Arruda Pecora; Vincenzo Pugliese; Luiz Augusto Carneiro D'Albuquerque; Edson Abdala Journal: World J Gastroenterol Date: 2014-05-14 Impact factor: 5.742