Literature DB >> 16546442

Novel approaches for therapy of chronic hepatitis C.

Rudolf E Stauber1, Vanessa Stadlbauer.   

Abstract

Currently available anti-HCV therapy is effective in only half of the patients and limited by side effects that often necessitate discontinuation. Therefore, new treatment strategies are being developed including (i) the optimization of current regimens, (ii) the use of additional agents working via novel mechanisms, and (iii) anti-fibrotic strategies. Many new antiviral compounds are now being studied in preclinical and clinical trials. This review will focus on drugs that have already entered the stage of phase 2 or phase 3 studies.

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Year:  2006        PMID: 16546442     DOI: 10.1016/j.jcv.2006.02.003

Source DB:  PubMed          Journal:  J Clin Virol        ISSN: 1386-6532            Impact factor:   3.168


  7 in total

Review 1.  Features of responding T cells in cancer and chronic infection.

Authors:  Peter S Kim; Rafi Ahmed
Journal:  Curr Opin Immunol       Date:  2010-03-06       Impact factor: 7.486

2.  Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA.

Authors:  Masahiko Takeshita; Yo-Ichi Ishida; Ena Akamatsu; Yusuke Ohmori; Masayuki Sudoh; Hirofumi Uto; Hirohito Tsubouchi; Hiroaki Kataoka
Journal:  J Biol Chem       Date:  2009-06-16       Impact factor: 5.157

3.  Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system.

Authors:  Leda Bassit; Jason Grier; Matthew Bennett; Raymond F Schinazi
Journal:  Antivir Chem Chemother       Date:  2008

4.  Relative replication capacity and selective advantage profiles of protease inhibitor-resistant hepatitis C virus (HCV) NS3 protease mutants in the HCV genotype 1b replicon system.

Authors:  Yupeng He; Martin S King; Dale J Kempf; Liangjun Lu; Hock Ben Lim; Preethi Krishnan; Warren Kati; Timothy Middleton; Akhteruzzaman Molla
Journal:  Antimicrob Agents Chemother       Date:  2007-12-17       Impact factor: 5.191

5.  Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication.

Authors:  Jong-Woo Kim; Sang Jin Park; Jong Hwan Lim; Jae Won Yang; Jung Cheul Shin; Sang Wook Lee; Joo Won Suh; Soon B Hwang
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-15       Impact factor: 2.629

6.  How to find simple and accurate rules for viral protease cleavage specificities.

Authors:  Thorsteinn Rögnvaldsson; Terence A Etchells; Liwen You; Daniel Garwicz; Ian Jarman; Paulo J G Lisboa
Journal:  BMC Bioinformatics       Date:  2009-05-16       Impact factor: 3.169

7.  Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance.

Authors:  Matteo Martino; Giulio Rocchi; Andrea Escelsior; Michele Fornaro
Journal:  Curr Neuropharmacol       Date:  2012-06       Impact factor: 7.363

  7 in total

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