Literature DB >> 16546381

Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.

Jun Chen1, Jun Liu, Luyong Zhang, Guanzhong Wu, Weiyi Hua, Xiaoming Wu, Hongbin Sun.   

Abstract

Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 microM) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed.

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Year:  2006        PMID： 16546381     DOI： 10.1016/j.bmcl.2006.03.009

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Amoebicidal Activity of Caffeine and Maslinic Acid by the Induction of Programmed Cell Death in Acanthamoeba.

Authors:  Carmen M Martín-Navarro; Atteneri López-Arencibia; Ines Sifaoui; María Reyes-Batlle; Emilie Fouque; Antonio Osuna; Basilio Valladares; José E Piñero; Yann Héchard; Sutherland K Maciver; Jacob Lorenzo-Morales
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

2.  Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter.

Authors:  Chutwadee Krisanapun; Seong-Ho Lee; Penchom Peungvicha; Rungravi Temsiririrkkul; Seung Joon Baek
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-17       Impact factor: 2.629

3.  Benzyl 3-dehydr-oxy-1,2,5-oxadiazolo[3',4':2,3]oleanolate.

Authors:  Jun Hu; Xiaoyun Gong; Ruji Wang; Yong Ju
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-15

Review 4.  Recent advances in synthesis and biological activity of triterpenic acylated oximes.

Authors:  Barbara Bednarczyk-Cwynar; Lucjusz Zaprutko
Journal:  Phytochem Rev       Date:  2014-04-11       Impact factor: 5.374

5.  Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes.

Authors:  Xue Wang; Yupeng Chen; Daoud Abdelkader; Waseem Hassan; Hongbin Sun; Jun Liu
Journal:  J Diabetes Res       Date:  2015-02-18       Impact factor: 4.011

Review 6.  Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases.

Authors:  Taiwo Betty Ayeleso; Mashudu Given Matumba; Emmanuel Mukwevho
Journal:  Molecules       Date:  2017-11-13       Impact factor: 4.411

Review 7.  Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.

Authors:  Jose M Castellano; Angeles Guinda; Teresa Delgado; Mirela Rada; Jose A Cayuela
Journal:  Diabetes       Date:  2013-06       Impact factor: 9.461

8.  Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines.

Authors:  Yu Pong Ng; Yuewen Chen; Yueqing Hu; Fanny C F Ip; Nancy Y Ip
Journal:  PLoS One       Date:  2013-05-16       Impact factor: 3.240

9.  Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives.

Authors:  Anna Pawełczyk; Dorota Olender; Katarzyna Sowa-Kasprzak; Lucjusz Zaprutko
Journal:  Molecules       Date:  2016-04-12       Impact factor: 4.411

Review 10.  Antiviral Activities of Oleanolic Acid and Its Analogues.

Authors:  Vuyolwethu Khwaza; Opeoluwa O Oyedeji; Blessing A Aderibigbe
Journal:  Molecules       Date:  2018-09-09       Impact factor: 4.411
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